Association of Genetic Variants of NLRP4 with Exacerbation of Asthma: The Effect of Smoking
- Authors
- Uh, Soo-Taek; Park, Jong-Sook; Koo, So-My; Kim, Yang-Ki; Kim, Ki Up; Kim, Mi-Ae; Shin, Seung-Woo; Son, Ji-Hye; Park, Heung-Woo; Shin, Hyoung Doo; Park, Choon-Sik; Chang, Hun Soo
- Issue Date
- 1-Jan-2019
- Publisher
- Mary Ann Liebert Inc.
- Keywords
- asthma; exacerbation; single nucleotide polymorphism; inflammasome; NLRP4; smoking; gene-environment interaction
- Citation
- DNA and Cell Biology, v.38, no.1, pp 76 - 84
- Pages
- 9
- Journal Title
- DNA and Cell Biology
- Volume
- 38
- Number
- 1
- Start Page
- 76
- End Page
- 84
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4795
- DOI
- 10.1089/dna.2018.4433
- ISSN
- 1044-5498
1557-7430
- Abstract
- Asthma exacerbation is induced by the interaction of genes and environmental factors such as cigarette smoke. NLRP4 counteracts the activity of the inflammasome, which is responsible for asthma exacerbation. In this study, we analyzed the association of single-nucleotide polymorphisms of NLRP4 with the annual rate of exacerbation and evaluated the additive effect of smoking in 1454 asthmatics. Asthmatics possessing the minor allele of rs1696718G > A had more frequent exacerbation episodes than those homozygous for the common allele (0.59 vs. 0.36/year) and the association was present only in current and ex-smokers. There was a significant interaction between the amount smoked and rs16986718 genotypes (p = 0.014) and a positive correlation between the number of annual exacerbation episodes and amount smoked only in rs16986718G > A AA homozygotes. The prevalence of frequent exacerbators (>= 2 exacerbation episodes/year) was 2.5 times higher in rs16986718G > A minor allele homozygotes than in common allele homozygotes (12.0% vs. 5.9%). Furthermore, the prevalence was 6 times higher in rs16986718G > A minor allele homozygotes who were current and ex-smokers than in nonsmokers (25.6% vs. 4.1%). The minor allele of rs16986718G > A in NLRP4 may be a genetic marker that predicts asthma exacerbation in adult asthmatics who smoke.
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Collections - College of Medicine > Soonchunhyang Institute of Medicine > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
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