Detailed Information
Cited 0 time in 
Cited 4 time in 
Cited 4 time in
Metadata Downloads
Chlorin e6 and halogen light as a sebostatic photomedicine modulates linoleic acid-induced lipogenesis
- Authors
- Ryu, A-Reum; Kim, Yong-Wan; Lee, Mi-Young
- Issue Date
- Jan-2019
- Publisher
- 대한독성 유전단백체 학회
- Keywords
- Ce6; Photodynamic therapy; Halogen light; Sebocytes; Anti-lipogenesis
- Citation
- Molecular & Cellular Toxicology, v.15, no.1, pp 49 - 56
- Pages
- 8
- Journal Title
- Molecular & Cellular Toxicology
- Volume
- 15
- Number
- 1
- Start Page
- 49
- End Page
- 56
- ISSN
- 1738-642X
2092-8467
- Abstract
- BackgroundsChlorin e6-mediated photodynamic therapy (Ce6-PDT) showed anti-microbial and anti-inflammatory effects on acne vulgaris model previously. Excess sebum production in sebocytes is a crucial cause of acne. However, information on the effect of Ce6-PDT associated with lipogenesis in sebocytes has not been reported so far.MethodsThe oil red O staining, triglyceride assay and cholesterol assay were used to investigate lipid synthesis in human sebocytes. The expressions of various molecular signals associated with lipogenesis were examined by western blot analysis.ResultsCe6-PDT reduced the lipid content of cultured sebocytes. The inactivation of Akt, mTOR, Raptor, PPAR and C/EBP, as well as the activation of AMPK, were revealed to be the molecular signals associated with sebostatic modulation by Ce6-PDT.ConclusionCe6-PDT using halogen light exerts antilipogenesis in sebocytes and may be utilized for the treatment of acne vulgaris.
- Files in This Item
- There are no files associated with this item.
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Related Researcher
- Lee, Mi young
- College of Medical Sciences (Department of Medical Biotechnology)