장내 미생물의 조절과 지방세포의 갈색지방화를 통한 비만 조절 연구
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 조예진 | - |
dc.contributor.author | 라만 엠디 샤밈 | - |
dc.contributor.author | 김용식 | - |
dc.date.accessioned | 2021-08-11T10:43:38Z | - |
dc.date.available | 2021-08-11T10:43:38Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1225-9918 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/5064 | - |
dc.description.abstract | Obesity, represented by abnormal fat accumulation due to an imbalance between energy intake and expenditure, is a major public health issue worldwide, leading to multiple noncommunicable diseases, including atherosclerosis, hypertension, type 2 diabetes, and cancer. Diverse solutions have been proposed to combat obesity. Attention has focused on two types of adipose tissues as a promising therapeutic target in obesity: traditional brown and beige or brite. Unlike energy-storing white adipose (endocrine) tissue, traditional brown adipose tissue and beige adipose tissue have energy-dissipating thermogenic properties. Both types of tissue are present in adult humans and inducible through external stimuli, such as cold exposure, β3-adrenergic receptor agonists, and phytochemicals. Among these stimuli, microbiota present in the human intestinal tract participate in multiple metabolic activities. Modulation of gut microbiota may offer a potent and possibly curative strategy against various metabolic diseases. Numerous studies have focused on the effects of established antiobesity treatments on the gut microenvironment or brown-adipose-tissue activation. In this review, we focus mainly on stimuli known to alleviate obesity, weight gain, and metabolic diseases, in addition to known and possible inter-relations between gut microbiota modulation and similar interventions and adipose tissue browning. The findings may pave the way toward new strategies against obesity. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 한국생명과학회 | - |
dc.title | 장내 미생물의 조절과 지방세포의 갈색지방화를 통한 비만 조절 연구 | - |
dc.title.alternative | Obesity Regulation through Gut Microbiota Modulation and Adipose Tissue Browning | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 김용식 | - |
dc.identifier.doi | 10.5352/JLS.2019.29.8.922 | - |
dc.identifier.bibliographicCitation | 생명과학회지, v.29, no.8, pp.922 - 940 | - |
dc.relation.isPartOf | 생명과학회지 | - |
dc.citation.title | 생명과학회지 | - |
dc.citation.volume | 29 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 922 | - |
dc.citation.endPage | 940 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART002498430 | - |
dc.description.journalClass | 2 | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Brown adipose tissue | - |
dc.subject.keywordAuthor | gut microbiota | - |
dc.subject.keywordAuthor | obesity | - |
dc.subject.keywordAuthor | thermogenesis | - |
dc.subject.keywordAuthor | Ucp1 | - |
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