장내 미생물의 조절과 지방세포의 갈색지방화를 통한 비만 조절 연구Obesity Regulation through Gut Microbiota Modulation and Adipose Tissue Browning
- Other Titles
- Obesity Regulation through Gut Microbiota Modulation and Adipose Tissue Browning
- Authors
- 조예진; 라만 엠디 샤밈; 김용식
- Issue Date
- 2019
- Publisher
- 한국생명과학회
- Keywords
- Brown adipose tissue; gut microbiota; obesity; thermogenesis; Ucp1
- Citation
- 생명과학회지, v.29, no.8, pp.922 - 940
- Journal Title
- 생명과학회지
- Volume
- 29
- Number
- 8
- Start Page
- 922
- End Page
- 940
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/5064
- DOI
- 10.5352/JLS.2019.29.8.922
- ISSN
- 1225-9918
- Abstract
- Obesity, represented by abnormal fat accumulation due to an imbalance between energy intake and expenditure, is a major public health issue worldwide, leading to multiple noncommunicable diseases, including atherosclerosis, hypertension, type 2 diabetes, and cancer. Diverse solutions have been proposed to combat obesity. Attention has focused on two types of adipose tissues as a promising therapeutic target in obesity: traditional brown and beige or brite. Unlike energy-storing white adipose (endocrine) tissue, traditional brown adipose tissue and beige adipose tissue have energy-dissipating thermogenic properties. Both types of tissue are present in adult humans and inducible through external stimuli, such as cold exposure, β3-adrenergic receptor agonists, and phytochemicals. Among these stimuli, microbiota present in the human intestinal tract participate in multiple metabolic activities. Modulation of gut microbiota may offer a potent and possibly curative strategy against various metabolic diseases. Numerous studies have focused on the effects of established antiobesity treatments on the gut microenvironment or brown-adipose-tissue activation. In this review, we focus mainly on stimuli known to alleviate obesity, weight gain, and metabolic diseases, in addition to known and possible inter-relations between gut microbiota modulation and similar interventions and adipose tissue browning. The findings may pave the way toward new strategies against obesity.
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Collections - College of Medicine > Department of Microbiology > 1. Journal Articles
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