Five-year clinical outcomes of first-generation versus second-generation drug-eluting stents following coronary chronic total occlusion intervention
- Authors
- Kim, Yong Hoon; Her, Ae-Young; Rha, Seung-Woon; Choi, Byoung Geol; Choi, Se Yeon; Byun, Jae Kyeong; Park, Yoonjee; Kang, Dong Oh; Jang, Won Young; Kim, Woohyeun; Baek, Ju Yeol; Choi, Woong Gil; Kang, Tae Soo; Ahn, Jihun; Park, Sang-Ho; Park, Ji Young; Lee, Min-Ho; Choi, Cheol Ung; Park, Chang Gyu; Seo, Hong Seog
- Issue Date
- 2019
- Publisher
- Institute of Geriatric Cardiology, Chinese PLA General Hospital
- Keywords
- Chronic total occlusion; Drug-eluting stent; Outcomes
- Citation
- Journal of Geriatric Cardiology, v.16, no.8, pp 639 - 647
- Pages
- 9
- Journal Title
- Journal of Geriatric Cardiology
- Volume
- 16
- Number
- 8
- Start Page
- 639
- End Page
- 647
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/5317
- DOI
- 10.11909/j.issn.1671-5411.2019.08.006
- ISSN
- 1671-5411
- Abstract
- Background There are limited data comparing long-term clinical outcomes between first-generation (1G) and second-generation (2G) drug-eluting stents (DESs) in patients who underwent successful percutaneous coronary intervention (PCI) for coronary chronic total occlusion (CTO) lesion. Methods A total of 840 consecutive patients who underwent PCI with DESs for CTO lesion from January 2004 to November 2015 were enrolled. Finally, a total of 324 eligible CTO patients received 1G-DES (Paclitaxel-eluting stent or Sirolimus-eluting stent, n = 157) or 2G-DES (Zotarolimus-eluting stent or Everolimus-eluting stent, n = 167) were enrolled. The clinical endpoint was the occurrence of major adverse cardiac events (MACE) defined as all-cause death, recurrent myocardial infarction (re-MI), total repeat revascularization [target lesion revascularization (TLR), target vessel revascularization (TVR), and non-TVR]. We investigated the 5-year major clinical outcomes between 1G-DES and 2G-DES in patient who underwent successful CTO PCI. Results After propensity score matched (PSM) analysis, two well-balanced groups (111 pairs, n = 222, C-statistic = 0.718) were generated. Up to the 5-year follow-up period, the cumulative incidence of all-cause death, re-MI, TLR, TVR and non-TVR were not significantly different between the two groups. Finally, MACE was also similar between the two groups (HR = 1.557, 95% CI: 0.820-2.959, P = 0.176) after PSM. Conclusions In this study, 2G-DES was not associated with reduced long-term MACE compared with 1G-DES following successful CTO revascularization up to five years.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/5317)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.