MiR-9 Controls Chemotactic Activity of Cord Blood CD34(+) Cells by Repressing CXCR4 Expression
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ha, Tae Won | - |
dc.contributor.author | Kang, Hyun Soo | - |
dc.contributor.author | Kim, Tae-Hee | - |
dc.contributor.author | Kwon, Ji Hyun | - |
dc.contributor.author | Kim, Hyun Kvu | - |
dc.contributor.author | Ryu, Aeli | - |
dc.contributor.author | Jeon, Hyeji | - |
dc.contributor.author | Han, Jaeseok | - |
dc.contributor.author | Broxmeyer, Hal E. | - |
dc.contributor.author | Hwang, Yongsung | - |
dc.contributor.author | Lee, Yun Kyung | - |
dc.contributor.author | Lee, Man Ryul | - |
dc.date.accessioned | 2021-08-11T11:24:10Z | - |
dc.date.available | 2021-08-11T11:24:10Z | - |
dc.date.issued | 2018-11 | - |
dc.identifier.issn | 2005-3606 | - |
dc.identifier.issn | 2005-5447 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/5518 | - |
dc.description.abstract | Improved approaches for promoting umbilical cord blood (CB) hematopoietic stem cell (HSC) homing are clinically important to enhance engraftment of CB-HSCs. Clinical transplantation of CB-HSCs is used to treat a wide range of disorders. however, an improved understanding of HSC chemotaxis is needed for facilitation of the engraftment process. We found that ectopic overexpression of miR-9 and antisense-miR-9 respectively down- and up-regulated C-X-C chemokine receptor type 4 (CXCR4) expression in CB-CD34(+) cells as well as in 293T and TF-1 cell lines. Since CXCR4 is a specific receptor for the stromal cell derived factor-1 (SDF-1) chemotactic factor, we investigated whether sense miR-9 and antisense miR-9 influenced CXCR4-mediated chemotactic mobility of primary CB-CD34(+) cells and TF-1 cells. Ectopic overexpression of sense miR-9 and antisense miR-9 respectively down- and up-regulated SDF-1-mediated chemotactic cell mobility. To our knowledge, this study is the first to report that miR-9 may play a role in regulating CXCR4 expression and SDF-1-mediated chemotactic activity of CB CD34(+) cells. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Korean Society for Stem Cell Research | - |
dc.title | MiR-9 Controls Chemotactic Activity of Cord Blood CD34(+) Cells by Repressing CXCR4 Expression | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.15283/ijsc18057 | - |
dc.identifier.scopusid | 2-s2.0-85057817600 | - |
dc.identifier.wosid | 000454044400005 | - |
dc.identifier.bibliographicCitation | International Journal of Stem Cells, v.11, no.2, pp 187 - 195 | - |
dc.citation.title | International Journal of Stem Cells | - |
dc.citation.volume | 11 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 187 | - |
dc.citation.endPage | 195 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell & Tissue Engineering | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | HUMAN HEMATOPOIETIC STEM | - |
dc.subject.keywordPlus | UMBILICAL-CORD | - |
dc.subject.keywordPlus | MICRORNA EXPRESSION | - |
dc.subject.keywordPlus | PROGENITOR CELLS | - |
dc.subject.keywordPlus | BONE-MARROW | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | ENGRAFTMENT | - |
dc.subject.keywordPlus | TARGETS | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordAuthor | microTRNA | - |
dc.subject.keywordAuthor | CXCR4 | - |
dc.subject.keywordAuthor | Cord blood | - |
dc.subject.keywordAuthor | Cell migration | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.