CEGP-003 Spray Has a Similar Hemostatic Effect to Epinephrine Injection in Cases of Acute Upper Gastrointestinal Bleeding
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bang, Byoung Wook | - |
dc.contributor.author | Lee, Don Haeng | - |
dc.contributor.author | Kim, Hyung Kil | - |
dc.contributor.author | Kwon, Kye Sook | - |
dc.contributor.author | Shin, Yong Woon | - |
dc.contributor.author | Hong, Su Jin | - |
dc.contributor.author | Moon, Jong Ho | - |
dc.date.accessioned | 2021-08-11T11:43:33Z | - |
dc.date.available | 2021-08-11T11:43:33Z | - |
dc.date.issued | 2018-11 | - |
dc.identifier.issn | 0163-2116 | - |
dc.identifier.issn | 1573-2568 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/5562 | - |
dc.description.abstract | BackgroundEndoscopically applicable hemostatic agents have been demonstrated to have high initial hemostasis rates in cases of upper gastrointestinal bleeding (UGIB).AimsThe authors developed a new hemostatic powder (CEGP-003) and evaluated its hemostatic and ulcer healing effects in UGIB.MethodsPatients with peptic ulcer or post-endoscopic resection bleeding were randomly assigned to be treated by epinephrine injection or CEGP-003 spray. All patients were placed under observation for 3days and underwent second-look endoscopy. The primary outcome was initial hemostasis rate, and the secondary outcomes were rebleeding rate and ulcer healing effect.ResultsSeventy-two patients with UGIB were enrolled in this study. Causes of bleeding were peptic ulcer (15, 20.5%), post-endoscopic mucosal resection (11, 15.1%), and post-endoscopic submucosal dissection bleeding (47, 64.4%). Initial hemostasis was achieved in 89.2% (34/37) of patients in the epinephrine group and in 100% (35/35) in the CEGP-003 group (p=0.115). Rebleeding occurred in 2.7% (1/37) and 8.6% (3/35) in the epinephrine and CEGP-003 groups, respectively (p=0.35). Three days after endoscopic hemostasis, the ulcer healing effects of epinephrine and CEGP-003 were similar (p=0.79).ConclusionThis study shows that CEGP-003 spray has a hemostatic effect similar to epinephrine in terms of initial hemostasis and rebleeding rates. The authors consider CEGP-003 a potential therapeutic tool for UGIB as a definitive or bridge therapy and that it is particularly useful for oozing lesions after endoscopic resection. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Kluwer Academic/Plenum Publishers | - |
dc.title | CEGP-003 Spray Has a Similar Hemostatic Effect to Epinephrine Injection in Cases of Acute Upper Gastrointestinal Bleeding | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1007/s10620-018-5208-z | - |
dc.identifier.wosid | 000447972900027 | - |
dc.identifier.bibliographicCitation | Digestive Diseases and Sciences, v.63, no.11, pp 3026 - 3032 | - |
dc.citation.title | Digestive Diseases and Sciences | - |
dc.citation.volume | 63 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 3026 | - |
dc.citation.endPage | 3032 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | ENDOSCOPIC APPLICATION | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | POWDER | - |
dc.subject.keywordPlus | ULCERS | - |
dc.subject.keywordAuthor | Gastrointestinal hemorrhage | - |
dc.subject.keywordAuthor | Hemostasis | - |
dc.subject.keywordAuthor | Endoscopic | - |
dc.subject.keywordAuthor | Hemostatic techniques | - |
dc.subject.keywordAuthor | Wound healing | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.