CEGP-003 Spray Has a Similar Hemostatic Effect to Epinephrine Injection in Cases of Acute Upper Gastrointestinal Bleeding
- Authors
- Bang, Byoung Wook; Lee, Don Haeng; Kim, Hyung Kil; Kwon, Kye Sook; Shin, Yong Woon; Hong, Su Jin; Moon, Jong Ho
- Issue Date
- Nov-2018
- Publisher
- Kluwer Academic/Plenum Publishers
- Keywords
- Gastrointestinal hemorrhage; Hemostasis; Endoscopic; Hemostatic techniques; Wound healing
- Citation
- Digestive Diseases and Sciences, v.63, no.11, pp 3026 - 3032
- Pages
- 7
- Journal Title
- Digestive Diseases and Sciences
- Volume
- 63
- Number
- 11
- Start Page
- 3026
- End Page
- 3032
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/5562
- DOI
- 10.1007/s10620-018-5208-z
- ISSN
- 0163-2116
1573-2568
- Abstract
- BackgroundEndoscopically applicable hemostatic agents have been demonstrated to have high initial hemostasis rates in cases of upper gastrointestinal bleeding (UGIB).AimsThe authors developed a new hemostatic powder (CEGP-003) and evaluated its hemostatic and ulcer healing effects in UGIB.MethodsPatients with peptic ulcer or post-endoscopic resection bleeding were randomly assigned to be treated by epinephrine injection or CEGP-003 spray. All patients were placed under observation for 3days and underwent second-look endoscopy. The primary outcome was initial hemostasis rate, and the secondary outcomes were rebleeding rate and ulcer healing effect.ResultsSeventy-two patients with UGIB were enrolled in this study. Causes of bleeding were peptic ulcer (15, 20.5%), post-endoscopic mucosal resection (11, 15.1%), and post-endoscopic submucosal dissection bleeding (47, 64.4%). Initial hemostasis was achieved in 89.2% (34/37) of patients in the epinephrine group and in 100% (35/35) in the CEGP-003 group (p=0.115). Rebleeding occurred in 2.7% (1/37) and 8.6% (3/35) in the epinephrine and CEGP-003 groups, respectively (p=0.35). Three days after endoscopic hemostasis, the ulcer healing effects of epinephrine and CEGP-003 were similar (p=0.79).ConclusionThis study shows that CEGP-003 spray has a hemostatic effect similar to epinephrine in terms of initial hemostasis and rebleeding rates. The authors consider CEGP-003 a potential therapeutic tool for UGIB as a definitive or bridge therapy and that it is particularly useful for oozing lesions after endoscopic resection.
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
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