The ameliorative effect of hemp seed hexane extracts on the Propionibacterium acnes-induced inflammation and lipogenesis in sebocytesopen access
- Authors
- Jin, Solee; Lee, Mi-Young
- Issue Date
- 27-Aug-2018
- Publisher
- Public Library of Science
- Keywords
- inflammation; lipogenesis
- Citation
- PLoS ONE, v.13, no.8
- Journal Title
- PLoS ONE
- Volume
- 13
- Number
- 8
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/5710
- DOI
- 10.1371/journal.pone.0202933
- ISSN
- 1932-6203
- Abstract
- In this study, we investigated the anti-microbial, anti-inflammatory, and anti-lipogenic effects of hemp (Cannabis sativa L.) seed hexane extracts, focusing on the Propionibacterium acnes-triggered inflammation and lipogenesis. Hemp seed hexane extracts (HSHE) showed anti-microbial activity against P. acnes. The expression of iNOS, COX-2, and the subsequent production of nitric oxide and prostaglandin increased after infection of P. acnes in HaCaT cells, however, upon treating with HSHE, their expressions were reduced. P. acnes induced expressions of IL-1 beta and IL-8 were also reduced. HSHE exerted anti-inflammatory effects by regulating NF-kappa B and MAPKs signaling and blunting the translocation of p-NF-kappa B to the nucleus in P. acnes-stimulated HaCaT cells. Moreover, P. acnes-induced phosphorylation of ERK and JNK, and their downstream targets c-Fos and c-Jun, was also inhibited by HSHE. In addition, the transactivation of AP-1 induced by P. acnes infection was also downregulated by HSHE. Notably, HSHE regulated inflammation and lipid biosynthesis via regulating AMPK and AKT/FoxO1 signaling in IGF-1-induced inflammation and lipogenesis of sebocytes. In addition, HSHE inhibited 5-lipoxygenase level and P. acnes-induced MMP-9 activity, and promoted collagen biosynthesis in vitro. Thus, HSHE could be utilized to treat acne vulgaris, through its anti-microbial, anti-inflammatory, anti-lipogenic, and collagen-promoting properties.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medical Sciences > Department of Medical Biotechnology > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/5710)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.