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Effects of Long-Distance Running on Cardiac Markers and Biomarkers in Exercise-Induced Hypertension Runners: An Observational Study

Authors
Park, Min-hoShin, Kyung-AKim, Chul-HyunLee, Yoon-HeePark, YongbumAhn, JaekiKim, Young-Joo
Issue Date
Aug-2018
Publisher
대한재활의학회
Keywords
Exercise; Hypertension; Blood pressure; Biomarkers; Running
Citation
Annals of Rehabilitation Medicine, v.42, no.4, pp 575 - 583
Pages
9
Journal Title
Annals of Rehabilitation Medicine
Volume
42
Number
4
Start Page
575
End Page
583
URI
https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/5769
DOI
10.5535/arm.2018.42.4.575
ISSN
2234-0645
2234-0653
Abstract
Objective To investigate changes of cardiac and muscle damage markers in exercise-induced hypertension (EIH) runners before running (pre-race), immediately after completing a 100-km ultramarathon race, and during the recovery period (24, 72, and 120 hours post-race). Methods In this observational study, volunteers were divided into EIH group (n=11) whose maximum systolic blood pressure was >= 210 mmHg in graded exercise testing and normal exercise blood pressure response (NEBPR) group (n=11). Their blood samples were collected at pre-race, immediately after race, and at 24, 72, and 120 hours post-race. Results Creatine kinase (CK) and cardiac troponin I (cTnI) levels were significantly higher in EIH group than those in the NEBPR group immediately after race and at 24 hours post-race (all p<0.05). However, lactate dehydrogenase (LDH), creatine kinase-myocardial band (CKMB), or CKMB/CK levels did not show any significant differences between the two groups in each period. N-terminal pro-brain natriuretic peptide (NT-proBNP) levels were significantly higher in EIH group than those in NEBPR group immediately after race and at 24 and 72 hours postrace (all p<0.05). A high sensitivity C-reactive protein (hs-CRP) level was significantly higher in EIH group than that in NEBPR group at 24 hours post-race (p<0.05). Conclusion The phenomenon of higher inflammatory and cardiac marker levels in EIH group may exaggerate cardiac volume pressure and blood flow restrictions which in turn can result in cardiac muscle damage. Further prospective studies are needed to investigate the chronic effect of such phenomenon on the cardiovascular system in EIH runners.
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