Fractionated Gamma Knife Radiosurgery as Initial Treatment for Large Skull Base Meningioma
DC Field | Value | Language |
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dc.contributor.author | Park, Hye Ran | - |
dc.contributor.author | Lee, Jae Meen | - |
dc.contributor.author | Park, Kwang-Woo | - |
dc.contributor.author | Kim, Jung Hoon | - |
dc.contributor.author | Jeong, Sang Soon | - |
dc.contributor.author | Kim, Jin Wook | - |
dc.contributor.author | Chung, Hyun-Tai | - |
dc.contributor.author | Kim, Dong Gyu | - |
dc.contributor.author | Paek, Sun Ha | - |
dc.date.accessioned | 2021-08-11T12:23:47Z | - |
dc.date.available | 2021-08-11T12:23:47Z | - |
dc.date.issued | 2018-06 | - |
dc.identifier.issn | 1226-2560 | - |
dc.identifier.issn | 2093-8144 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/5936 | - |
dc.description.abstract | We present our experience on the hypofractionated Gamma Knife radiosurgery (FGKS) for large skull base meningioma as an initial treatment. We retrospectively reviewed 23 patients with large skull base meningioma >= 10 cm(3) who underwent FGKS as the initial treatment option. The mean volume of tumors prior to radiosurgery was 21.2+/-15.63 cm(3) (range, 10.09 similar to 71.42). The median total margin dose and marginal dose per fraction were 18 Gy (range, 15 similar to 20) and 6 Gy (range, 5 similar to 6), respectively. Patients underwent three or four fractionations in consecutive days with the same Leksell (R) frame. The mean follow-up duration was 38 months (range, 17 similar to 78). There was no mortality. At the last follow-up, the tumor volume was stationary in 15 patients (65.2%) and had decreased in 8 patients (34.8%). Six patients who had cranial neuropathy at the time of FGKS showed improvement at the last clinical follow-up. Following FGKS, 4 patients (17%) had new cranial neuropathy. The trigeminal neuropathy was the most common and all were transient. The mean Karnofsky Performance Status score at pre-FGKS and the last clinical follow-up was 97.0+/-10.4 points (median, 100) and 98.6+/-6.9 (median, 100) points, respectively. FGKS has showed satisfactory tumor control with functional preservation for large skull base meningiomas. Further prospective studies of large cohorts with long term follow-up are required to clarify the efficacy in the tumor control and functional outcome as well as radiation toxicity. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 한국뇌신경과학회 | - |
dc.title | Fractionated Gamma Knife Radiosurgery as Initial Treatment for Large Skull Base Meningioma | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.5607/en.2018.27.3.245 | - |
dc.identifier.scopusid | 2-s2.0-85050113293 | - |
dc.identifier.wosid | 000439000700011 | - |
dc.identifier.bibliographicCitation | Experimental Neurobiology, v.27, no.3, pp 245 - 255 | - |
dc.citation.title | Experimental Neurobiology | - |
dc.citation.volume | 27 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 245 | - |
dc.citation.endPage | 255 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002368554 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | STEREOTACTIC RADIOSURGERY | - |
dc.subject.keywordPlus | PETROCLIVAL MENINGIOMAS | - |
dc.subject.keywordPlus | TUMOR-CONTROL | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | INTRACRANIAL MENINGIOMAS | - |
dc.subject.keywordPlus | CYBERKNIFE RADIOSURGERY | - |
dc.subject.keywordPlus | PERIOPTIC LESIONS | - |
dc.subject.keywordPlus | EXPERIENCE | - |
dc.subject.keywordPlus | RADIOTHERAPY | - |
dc.subject.keywordPlus | SURGERY | - |
dc.subject.keywordAuthor | Gamma Knife Radiosurgery | - |
dc.subject.keywordAuthor | Dose Hypofractionation | - |
dc.subject.keywordAuthor | Meningioma | - |
dc.subject.keywordAuthor | Skull Base | - |
dc.subject.keywordAuthor | Stereotactic Radiosurgery | - |
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