Fractionated Gamma Knife Radiosurgery as Initial Treatment for Large Skull Base Meningioma
- Authors
- Park, Hye Ran; Lee, Jae Meen; Park, Kwang-Woo; Kim, Jung Hoon; Jeong, Sang Soon; Kim, Jin Wook; Chung, Hyun-Tai; Kim, Dong Gyu; Paek, Sun Ha
- Issue Date
- Jun-2018
- Publisher
- 한국뇌신경과학회
- Keywords
- Gamma Knife Radiosurgery; Dose Hypofractionation; Meningioma; Skull Base; Stereotactic Radiosurgery
- Citation
- Experimental Neurobiology, v.27, no.3, pp 245 - 255
- Pages
- 11
- Journal Title
- Experimental Neurobiology
- Volume
- 27
- Number
- 3
- Start Page
- 245
- End Page
- 255
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/5936
- DOI
- 10.5607/en.2018.27.3.245
- ISSN
- 1226-2560
2093-8144
- Abstract
- We present our experience on the hypofractionated Gamma Knife radiosurgery (FGKS) for large skull base meningioma as an initial treatment. We retrospectively reviewed 23 patients with large skull base meningioma >= 10 cm(3) who underwent FGKS as the initial treatment option. The mean volume of tumors prior to radiosurgery was 21.2+/-15.63 cm(3) (range, 10.09 similar to 71.42). The median total margin dose and marginal dose per fraction were 18 Gy (range, 15 similar to 20) and 6 Gy (range, 5 similar to 6), respectively. Patients underwent three or four fractionations in consecutive days with the same Leksell (R) frame. The mean follow-up duration was 38 months (range, 17 similar to 78). There was no mortality. At the last follow-up, the tumor volume was stationary in 15 patients (65.2%) and had decreased in 8 patients (34.8%). Six patients who had cranial neuropathy at the time of FGKS showed improvement at the last clinical follow-up. Following FGKS, 4 patients (17%) had new cranial neuropathy. The trigeminal neuropathy was the most common and all were transient. The mean Karnofsky Performance Status score at pre-FGKS and the last clinical follow-up was 97.0+/-10.4 points (median, 100) and 98.6+/-6.9 (median, 100) points, respectively. FGKS has showed satisfactory tumor control with functional preservation for large skull base meningiomas. Further prospective studies of large cohorts with long term follow-up are required to clarify the efficacy in the tumor control and functional outcome as well as radiation toxicity.
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Collections - College of Medicine > Department of Neurosurgery > 1. Journal Articles
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