Increased Risk of Atrial Fibrillation in the Early Period after Herpes Zoster Infection: a Nationwide Populationbased Case-control Study
- Authors
- Cha, Myung-Jin; Seo, Hyun-Min; Choi, Eue-Keun; Lee, Ji Hyun; Han, Kyungdo; Lee, So-Ryoung; Lim, Woo-Hyun; Park, Young Min; Oh, Seil
- Issue Date
- 28-May-2018
- Publisher
- 대한의학회
- Keywords
- Atrial Fibrillation; Herpes Zoster; Inflammation; Autonomic Dysfunction
- Citation
- Journal of Korean Medical Science, v.33, no.22
- Journal Title
- Journal of Korean Medical Science
- Volume
- 33
- Number
- 22
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/5965
- DOI
- 10.3346/jkms.2018.33.e160
- ISSN
- 1011-8934
1598-6357
- Abstract
- Background: Herpes zoster (HZ) is a chronic inflammatory disease that could result in autonomic dysfunction, often leading to atrial fibrillation (AF). Methods: From the Korean National Health Insurance Service database of 738,559 subjects, patients newly diagnosed with HZ (n = 30,685) between 2004 and 2011, with no history of HZ or AF were identified. For the non-HZ control group, 122,740 age- and sex-matched subjects were selected. AF development in the first two-years following HZ diagnosis, and during the overall follow-up period were compared among severe (requiring hospitalization, n = 2,213), mild (n = 28,472), and non-HZ (n = 122,740) groups. Results: There were 2,204 (1.4%) patients diagnosed with AF during follow-up, and 825 (0.5%) were diagnosed within the first two years after HZ. The severe HZ group showed higher rates of AF development (6.4 per 1,000 patient-years [PTPY]) compared to mild-HZ group (2.9 PTPY) and non-HZ group (2.7 PTPY). The risk of developing AF was higher in the first two-years after HZ diagnosis in the severe HZ group (10.6 PTPY vs. 2.7 PTPY in mild-HZ group and 2.6 PTPY in non-HZ group). Conclusion: Severe HZ that requires hospitalization shows an increased risk of incident AF, and the risk is higher in the first two-years following HZ diagnosis.
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