Subclinical Hypothyroidism and Incident Depression in Young and Middle-Age Adults
DC Field | Value | Language |
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dc.contributor.author | Kim, Ji Sun | - |
dc.contributor.author | Zhang, Yiyi | - |
dc.contributor.author | Chang, Yoosoo | - |
dc.contributor.author | Ryu, Seungho | - |
dc.contributor.author | Guallar, Eliseo | - |
dc.contributor.author | Shin, Young-Chul | - |
dc.contributor.author | Shin, Hocheol | - |
dc.contributor.author | Lim, Se-Won | - |
dc.contributor.author | Cho, Juhee | - |
dc.date.accessioned | 2021-08-11T12:24:05Z | - |
dc.date.available | 2021-08-11T12:24:05Z | - |
dc.date.issued | 2018-05 | - |
dc.identifier.issn | 0021-972X | - |
dc.identifier.issn | 1945-7197 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/6021 | - |
dc.description.abstract | Background: The role of subclinical hypothyroidism in the development of depression remains controversial. We examined the prospective association between subclinical hypothyroidism and incident depressive symptoms. Methods: We conducted a prospective cohort study of 220,545 middle-age adults without depression who had undergone at least two comprehensive health examinations between 1 January 2011 and 31 December 2014. Thyroid-stimulating hormone, free triiodothyronine (FT3), and free thyroxine (FT4) levels were measured using an electrochemiluminescent immunoassay. The study outcome was incident depressive symptoms, defined as a Center for Epidemiologic Studies-Depression score >16. Results: During a median follow-up period of 2 years, incident depressive symptoms occurred in 7323 participants. The multivariable-adjusted hazard ratio for incident depressive symptoms comparing subclinical hypothyroid and euthyroid participants was 0.97 (95% confidence interval, 0.87 to 1.09). Similarly, among euthyroid participants (n = 87,822), no apparent association was found between thyroid hormone levels and an increased risk of incident depressive symptoms. Conclusions: No apparent association was found between subclinical hypothyroidism and incident depressive symptoms in a large prospective cohort of middle-age men and women. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | The Endocrine Society | - |
dc.title | Subclinical Hypothyroidism and Incident Depression in Young and Middle-Age Adults | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1210/jc.2017-01247 | - |
dc.identifier.scopusid | 2-s2.0-85047196711 | - |
dc.identifier.wosid | 000432309500010 | - |
dc.identifier.bibliographicCitation | Journal of Clinical Endocrinology and Metabolism, v.103, no.5, pp 1827 - 1833 | - |
dc.citation.title | Journal of Clinical Endocrinology and Metabolism | - |
dc.citation.volume | 103 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1827 | - |
dc.citation.endPage | 1833 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | CORONARY-ARTERY CALCIFICATION | - |
dc.subject.keywordPlus | QUALITY-OF-LIFE | - |
dc.subject.keywordPlus | SCALE CES-D | - |
dc.subject.keywordPlus | THYROID-HORMONES | - |
dc.subject.keywordPlus | CRITERION VALIDITY | - |
dc.subject.keywordPlus | COGNITIVE FUNCTION | - |
dc.subject.keywordPlus | SYMPTOMS | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | DISORDERS | - |
dc.subject.keywordPlus | HEALTH | - |
dc.subject.keywordAuthor | Subclinical hypothyroidism and incident depression in young and middle age adults | - |
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