Subclinical Hypothyroidism and Incident Depression in Young and Middle-Age Adults
- Authors
- Kim, Ji Sun; Zhang, Yiyi; Chang, Yoosoo; Ryu, Seungho; Guallar, Eliseo; Shin, Young-Chul; Shin, Hocheol; Lim, Se-Won; Cho, Juhee
- Issue Date
- May-2018
- Publisher
- The Endocrine Society
- Keywords
- Subclinical hypothyroidism and incident depression in young and middle age adults
- Citation
- Journal of Clinical Endocrinology and Metabolism, v.103, no.5, pp 1827 - 1833
- Pages
- 7
- Journal Title
- Journal of Clinical Endocrinology and Metabolism
- Volume
- 103
- Number
- 5
- Start Page
- 1827
- End Page
- 1833
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/6021
- DOI
- 10.1210/jc.2017-01247
- ISSN
- 0021-972X
1945-7197
- Abstract
- Background: The role of subclinical hypothyroidism in the development of depression remains controversial. We examined the prospective association between subclinical hypothyroidism and incident depressive symptoms. Methods: We conducted a prospective cohort study of 220,545 middle-age adults without depression who had undergone at least two comprehensive health examinations between 1 January 2011 and 31 December 2014. Thyroid-stimulating hormone, free triiodothyronine (FT3), and free thyroxine (FT4) levels were measured using an electrochemiluminescent immunoassay. The study outcome was incident depressive symptoms, defined as a Center for Epidemiologic Studies-Depression score >16. Results: During a median follow-up period of 2 years, incident depressive symptoms occurred in 7323 participants. The multivariable-adjusted hazard ratio for incident depressive symptoms comparing subclinical hypothyroid and euthyroid participants was 0.97 (95% confidence interval, 0.87 to 1.09). Similarly, among euthyroid participants (n = 87,822), no apparent association was found between thyroid hormone levels and an increased risk of incident depressive symptoms. Conclusions: No apparent association was found between subclinical hypothyroidism and incident depressive symptoms in a large prospective cohort of middle-age men and women.
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Collections - College of Medicine > Department of Psychiatry > 1. Journal Articles
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