Clinicopathological and prognostic significance of heme oxygenase-1 expression in small intestinal adenocarcinomas
- Authors
- Jun, Sun-Young; Hong, Seung-Mo; Bae, Young Kyung; Kim, Hee Kyung; Jang, Kyu Yun; Eom, Dae Woon
- Issue Date
- May-2018
- Publisher
- Blackwell Publishing Inc.
- Keywords
- heme oxygenase-1; immunohistochemistry; small intestine; survival
- Citation
- Pathology International, v.68, no.5, pp 294 - 300
- Pages
- 7
- Journal Title
- Pathology International
- Volume
- 68
- Number
- 5
- Start Page
- 294
- End Page
- 300
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/6025
- DOI
- 10.1111/pin.12657
- ISSN
- 1320-5463
1440-1827
- Abstract
- Heme oxygenase-1 (HO-1), a stress-response protein, is highly induced in various carcinomas. It is implicated in carcinogenesis and tumor progression. High HO-1 expression is associated with better prognosis of patients with colorectal and gastric cancers. Induction or inhibition of HO-1 can mediate chemo-sensitivity, therefore it might be a therapeutic target to develop anticancer agents. To define the clinicopathological and prognostic significance of HO-1 expression in small-intestinal adenocarcinomas (SIACs), immunohistochemical microarray analysis of HO-1 expression was performed for 191 surgically resected SIAC cases and results were compared with various clinicopathologic variables, including survival. HO-1 was highly expressed in 127 (66.5%) cases. Patients with high HO-1 expression were associated with younger age (P=0.048), lower pT category (P=0.017), and less pancreatic invasion (P=0.047). Patients with high HO-1 expression tended to have longer overall survival (median, 38.5 months) than those with low HO-1 expression (24.5 months), although the difference in overall survival was not statistically significant (P=0.677). In summary, high HO-1 expression is frequently observed in SIACs. It is related to favorable clinicopathologic parameters, including younger age, lower T category, and less pancreatic invasion. Therefore, HO-1 may serve as a prognostic marker and a new target to modulate chemotherapeutic effects in patients with SIACs.
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Collections - College of Medicine > Department of Pathology > 1. Journal Articles
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