Effect of pre existing respiratory conditions on survival of lung cancer patients: A nationwide population-based cohort study
DC Field | Value | Language |
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dc.contributor.author | Hong, Seri | - |
dc.contributor.author | Park, Eun-Cheol | - |
dc.contributor.author | Kim, Tae Hyun | - |
dc.contributor.author | Kwon, Jeoung A. | - |
dc.contributor.author | Yoo, Ki-Bong | - |
dc.contributor.author | Han, Kyu-Tae | - |
dc.contributor.author | Yoo, Ji Won | - |
dc.contributor.author | Kim, Sun Jung | - |
dc.date.accessioned | 2021-08-11T12:24:14Z | - |
dc.date.available | 2021-08-11T12:24:14Z | - |
dc.date.issued | 2018-04 | - |
dc.identifier.issn | 1743-7555 | - |
dc.identifier.issn | 1743-7563 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/6068 | - |
dc.description.abstract | BackgroundCommon diseases with potential to increase the risk of death from lung cancer have so far not been studied in large populations. MethodsWe did a population-based retrospective cohort study using nationwide health insurance claims data from 2005 to 2012 in Korea including 205403 lung cancer patients. Multivariate-adjusted hazard ratios (aHRs) of lung cancer mortality by presence, time intervals with lung cancer diagnosis and combinations of pre-existing chronic obstructive pulmonary disease (COPD), pneumonia, asthma and tuberculosis were calculated using the Cox-proportional hazards model. ResultsThe total number of person-years of follow-up was 397780 and 60.2% of patients died (mean survival 23.2 months after lung cancer diagnosis). Lung cancer patients with previous respiratory disease had increased aHR for mortality (COPD, hazard ratio [HR]=1.32, CI 1.29-1.35; pneumonia, HR=1.14, CI 1.08-1.19; and asthma, HR=1.11, CI 1.06-1.16). Risks were positively associated with longer duration of pre-existing disease diagnosis; cases with >5 years since diagnosis compared to <2 years: COPD, HR=2.91, CI 2.82-3.00; pneumonia, HR=1.67, CI 1.51-1.85; asthma, HR=1.56, CI 1.45-1.68; and tuberculosis, HR=2.03, CI 1.90-2.17. Furthermore, elevated HRs of death were found among patients with multiple pre-existing co-morbidities. ConclusionHazards of death from lung cancer are significantly increased in cases with pre-existing lung disease, and worse with longer durations, and with multiple combinations before cancer diagnosis. Patients and physicians should be aware of these meaningful risk/prognostic factors for lung cancer when identifying high-risk patient groups. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Blackwell Pub. Asia | - |
dc.title | Effect of pre existing respiratory conditions on survival of lung cancer patients: A nationwide population-based cohort study | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1111/ajco.12697 | - |
dc.identifier.scopusid | 2-s2.0-85026524681 | - |
dc.identifier.wosid | 000427463600011 | - |
dc.identifier.bibliographicCitation | Asia-Pacific Journal of Clinical Oncology, v.14, no.2, pp E71 - E80 | - |
dc.citation.title | Asia-Pacific Journal of Clinical Oncology | - |
dc.citation.volume | 14 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | E71 | - |
dc.citation.endPage | E80 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | OBSTRUCTIVE PULMONARY-DISEASE | - |
dc.subject.keywordPlus | PNEUMONIAE INFECTION | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | TUBERCULOSIS | - |
dc.subject.keywordPlus | SMOKING | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | HISTORY | - |
dc.subject.keywordPlus | XUANWEI | - |
dc.subject.keywordPlus | ASTHMA | - |
dc.subject.keywordPlus | TRENDS | - |
dc.subject.keywordAuthor | lung neoplasms | - |
dc.subject.keywordAuthor | pre-existing condition | - |
dc.subject.keywordAuthor | respiratory tract diseases | - |
dc.subject.keywordAuthor | survival | - |
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