Effect of pre existing respiratory conditions on survival of lung cancer patients: A nationwide population-based cohort study
- Authors
- Hong, Seri; Park, Eun-Cheol; Kim, Tae Hyun; Kwon, Jeoung A.; Yoo, Ki-Bong; Han, Kyu-Tae; Yoo, Ji Won; Kim, Sun Jung
- Issue Date
- Apr-2018
- Publisher
- Blackwell Pub. Asia
- Keywords
- lung neoplasms; pre-existing condition; respiratory tract diseases; survival
- Citation
- Asia-Pacific Journal of Clinical Oncology, v.14, no.2, pp E71 - E80
- Journal Title
- Asia-Pacific Journal of Clinical Oncology
- Volume
- 14
- Number
- 2
- Start Page
- E71
- End Page
- E80
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/6068
- DOI
- 10.1111/ajco.12697
- ISSN
- 1743-7555
1743-7563
- Abstract
- BackgroundCommon diseases with potential to increase the risk of death from lung cancer have so far not been studied in large populations. MethodsWe did a population-based retrospective cohort study using nationwide health insurance claims data from 2005 to 2012 in Korea including 205403 lung cancer patients. Multivariate-adjusted hazard ratios (aHRs) of lung cancer mortality by presence, time intervals with lung cancer diagnosis and combinations of pre-existing chronic obstructive pulmonary disease (COPD), pneumonia, asthma and tuberculosis were calculated using the Cox-proportional hazards model. ResultsThe total number of person-years of follow-up was 397780 and 60.2% of patients died (mean survival 23.2 months after lung cancer diagnosis). Lung cancer patients with previous respiratory disease had increased aHR for mortality (COPD, hazard ratio [HR]=1.32, CI 1.29-1.35; pneumonia, HR=1.14, CI 1.08-1.19; and asthma, HR=1.11, CI 1.06-1.16). Risks were positively associated with longer duration of pre-existing disease diagnosis; cases with >5 years since diagnosis compared to <2 years: COPD, HR=2.91, CI 2.82-3.00; pneumonia, HR=1.67, CI 1.51-1.85; asthma, HR=1.56, CI 1.45-1.68; and tuberculosis, HR=2.03, CI 1.90-2.17. Furthermore, elevated HRs of death were found among patients with multiple pre-existing co-morbidities. ConclusionHazards of death from lung cancer are significantly increased in cases with pre-existing lung disease, and worse with longer durations, and with multiple combinations before cancer diagnosis. Patients and physicians should be aware of these meaningful risk/prognostic factors for lung cancer when identifying high-risk patient groups.
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Collections - College of Medical Sciences > Department of Health Administration and Management > 1. Journal Articles
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