Agomelatine co-crystals with resorcinol and hydroquinone: Preparation and characterization
- Authors
- Lee, Min-Jeong; Chun, Nan-Hee; Kim, Hyo-Cheol; Kim, Moon-Jip; Kim, Paul; Cho, Min-Yong; Choi, Guang Jin
- Issue Date
- Apr-2018
- Publisher
- 한국화학공학회
- Keywords
- Co-crystal; Agomelatine; Resorcinol; Hydroquinone; Solubility
- Citation
- Korean Journal of Chemical Engineering, v.35, no.4, pp 984 - 993
- Pages
- 10
- Journal Title
- Korean Journal of Chemical Engineering
- Volume
- 35
- Number
- 4
- Start Page
- 984
- End Page
- 993
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/6081
- DOI
- 10.1007/s11814-017-0347-z
- ISSN
- 0256-1115
1975-7220
- Abstract
- We prepared and characterized co-crystals of the antidepressant drug agomelatine with pharmaceutically acceptable coformers for enhanced solubility. A novel agomelatine-resorcinol (AGO-RES, 2 : 1) co-crystal was synthesized and its crystal structure was confirmed via single crystal X-ray diffraction. The AGO-RES co-crystal structure was created through the O-Ha (TM) a (TM) a (TM) O and N-Ha (TM) a (TM) a (TM) O hydrogen bonding between the phenolic OH of RES and the amide group of AGO. The chemical structure of two AGO co-crystals was characterized by FT-IR and Raman spectroscopies, whereas the solution behavior was determined by the intrinsic dissolution rate. When tested in water, both AGORES and AGO-HYQ form-I co-crystals showed higher apparent solubility than pure AGO. But the resulting AGO solution in a supersaturated state partially precipitated into specific crystal forms of AGO. As anticipated, the intrinsic dissolution rate of AGO was substantially enhanced by the co-crystal forms, which signifies that the bioavailability of AGO can be increased via co-crystal formulation approach.
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Collections - College of Medical Sciences > Department of Pharmaceutical Engineering > 1. Journal Articles
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