Multi-channel biphasic calcium phosphate granules as cell carrier capable of supporting osteogenic priming of mesenchymal stem cells
DC Field | Value | Language |
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dc.contributor.author | Abueva, Celine D. G. | - |
dc.contributor.author | Park, Chan Mi | - |
dc.contributor.author | Kim, Boram | - |
dc.contributor.author | Lee, Byong-Taek | - |
dc.date.accessioned | 2021-08-11T12:24:21Z | - |
dc.date.available | 2021-08-11T12:24:21Z | - |
dc.date.issued | 2018-03-05 | - |
dc.identifier.issn | 0264-1275 | - |
dc.identifier.issn | 1873-4197 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/6107 | - |
dc.description.abstract | Advances in bone tissue engineering include versatile and intricate biomaterial scaffolds in combination with stem cells for enhanced bone regeneration. In this study, a unique scaffold with multi-channels designed to allow cell infiltration within its pores was investigated for its capability to serve as a stable platform for adhesion and osteogenic priming of mesenchymal stem cells. The biphasic calcium phosphate multi-channel granule consisted of 60% hydroxyapatite and 40% beta-tricalcium phosphate. Successful loading and retention of isolated and expanded rat bone marrow-derived mesenchymal stem cells (rBMSCs) were observed. The cells proliferated within the micro-channels starting from the surface then into the channels. The multi-channel granules were also able to support osteogenic priming of rBMSCs in 2D culture without the aid of a growth factor. Alkaline phosphatase, type I collagen, and runt-related transcription factor 2 expressions were detected with high osteopontin marker expression in as early as 7 days, which persisted for 14 days of culture under osteogenic condition. Results confirmed commitment towards osteogenic lineage of rBMSCs that have attached and grown onto the surface of the multi-channel granules and thus have high potential as a cell-scaffold based approach in bone regenerative medicine. (C) 2017 Published by Elsevier Ltd. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | Multi-channel biphasic calcium phosphate granules as cell carrier capable of supporting osteogenic priming of mesenchymal stem cells | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1016/j.matdes.2017.12.040 | - |
dc.identifier.scopusid | 2-s2.0-85039415242 | - |
dc.identifier.wosid | 000424945300015 | - |
dc.identifier.bibliographicCitation | Materials & Design, v.141, pp 142 - 149 | - |
dc.citation.title | Materials & Design | - |
dc.citation.volume | 141 | - |
dc.citation.startPage | 142 | - |
dc.citation.endPage | 149 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | BONE | - |
dc.subject.keywordPlus | SCAFFOLDS | - |
dc.subject.keywordPlus | BIOMATERIALS | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.subject.keywordPlus | COMBINATION | - |
dc.subject.keywordPlus | CERAMICS | - |
dc.subject.keywordAuthor | Multi-channel granule | - |
dc.subject.keywordAuthor | Cell carrier | - |
dc.subject.keywordAuthor | Scaffold | - |
dc.subject.keywordAuthor | Stem cell | - |
dc.subject.keywordAuthor | Bone | - |
dc.subject.keywordAuthor | Regenerative medicine | - |
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