Intestinal microbiota and the immune system in metabolic diseases
- Authors
- Sittipo, Panida; Lobionda, Stefani; Lee, Yun Kyung; Maynard, Craig L.
- Issue Date
- Mar-2018
- Publisher
- 한국미생물학회
- Keywords
- dysbiosis; intestinal microbiota; intestinal barrier; immune system; metabolic disease
- Citation
- The Journal of Microbiology, v.56, no.3, pp 154 - 162
- Pages
- 9
- Journal Title
- The Journal of Microbiology
- Volume
- 56
- Number
- 3
- Start Page
- 154
- End Page
- 162
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/6186
- DOI
- 10.1007/s12275-018-7548-y
- ISSN
- 1225-8873
1976-3794
- Abstract
- The intestinal microbiota is comprised of millions of microorganisms that reside in the gastrointestinal tract and consistently interact with the host. Host factors such as diet and disease status affect the composition of the microbiota, while the microbiota itself produces metabolites that can further manipulate host physiology. Dysbiosis of the intestinal microbiota has been characterized in patients with certain metabolic diseases, some of which involve damage to the host intestinal epithelial barrier and alterations in the immune system. In this review, we will discuss the consequences of dietdependent bacterial dysbiosis in the gastrointestinal tract, and how the associated interaction with epithelial and immune cells impacts metabolic diseases.
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- Appears in
Collections - Graduate School > Department of Integrated Biomedical Science > 1. Journal Articles
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