Clinical Effectiveness of Submucosal Injection with Indigo Carmine Mixed Solution for Colon Endoscopic Mucosal Resection
- Authors
- Han, Su Jung; Jung, Yunho; Cho, Young Sin; Chung, Il-Kwun; Kim, Jae Yun; Eun, Jun Young; Lee, Seoung Ho; Ko, Gyu Bong; Lee, Tae Hoon; Park, Sang Hum; Cho, Hyun Deuk; Kim, Sun-Joo
- Issue Date
- Mar-2018
- Publisher
- Kluwer Academic/Plenum Publishers
- Keywords
- Colon endoscopic mucosal resection; Complete resection rate; Indigo carmine; Sessile serrated adenomas/polyps; Submucosal injection
- Citation
- Digestive Diseases and Sciences, v.63, no.3, pp 775 - 780
- Pages
- 6
- Journal Title
- Digestive Diseases and Sciences
- Volume
- 63
- Number
- 3
- Start Page
- 775
- End Page
- 780
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/6188
- DOI
- 10.1007/s10620-018-4918-6
- ISSN
- 0163-2116
1573-2568
- Abstract
- Submucosal injection with indigo carmine mixed solution can improve the delineation of colorectal neoplasia during endoscopic mucosal resection (EMR). Thus, the aim of this study was to evaluate the efficacy of submucosal injection with indigo carmine mixed solution during EMR of colorectal neoplasia. This was a prospective, randomized, controlled study of a total of 212 neoplastic colon polyps (5-20 mm) subjected to EMR in a single tertiary university hospital. The patients were randomized into two groups according to whether or not indigo carmine mixed solution was used, and the complete resection rate (CRR) after EMR was evaluated. A total of 212 neoplastic polyps (normal saline group, 115; indigo carmine group, 97) were successfully removed by EMR. There was no significant difference in the CRR (92.8 vs. 89.6%, p = 0.414) or macroscopic delineation (86.0 vs. 93.8%, p = 0.118) between the two groups. In a separate analysis of sessile serrated adenomas/polyps (SSAs/Ps), macroscopic delineation was better in the indigo carmine group than the normal saline group (87.5 vs. 53.8%), albeit not significantly (p = 0.103). In univariate analyses, the CRR was significantly related to polyp location, polyp morphology, macroscopic delineation, and pathologic findings. In a multiple logistic regression analysis, macroscopic delineation (odds ratio (OR), 7.616, p = 0.001) and polyp pathology (OR, 8.621; p < 0.001) were significantly associated with the CRR. Submucosal injection with indigo carmine mixed solution did not improve the CRR or macroscopic delineation of EMR of colorectal neoplasias.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Pathology > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/6188)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.