Bacopa monnieri extract improves novel object recognition, cell proliferation, neuroblast differentiation, brain-derived neurotrophic factor, and phosphorylation of cAMP response element-binding protein in the dentate gyrusBacopa monnieri extract improves novel object recognition, cell proliferation, neuroblast differentiation, brain-derived neurotrophic factor, and phosphorylation of cAMP response element-binding protein in the dentate gyrus
- Other Titles
- Bacopa monnieri extract improves novel object recognition, cell proliferation, neuroblast differentiation, brain-derived neurotrophic factor, and phosphorylation of cAMP response element-binding protein in the dentate gyrus
- Authors
- 권현정; 정효영; 한규리; 김우석; 김종휘; 유대영; 윤여성; 황인구; 김대원
- Issue Date
- 2018
- Publisher
- 한국실험동물학회
- Keywords
- Bacopa monnieri extract; dentate gyrus; novel object recognition; neurogenesis; brain-derived neurotrophic factor
- Citation
- Laboratory Animal Research, v.34, no.4, pp 239 - 247
- Pages
- 9
- Journal Title
- Laboratory Animal Research
- Volume
- 34
- Number
- 4
- Start Page
- 239
- End Page
- 247
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/6449
- DOI
- 10.5625/lar.2018.34.4.239
- ISSN
- 1738-6055
2233-7660
- Abstract
- Bacopa monnieri is a medicinal plant with a long history of use in Ayurveda, especially in the treatment of poor memory and cognitive deficits. In the present study, we hypothesized that Bacopa monnieri extract (BME) can improve memory via increased cell proliferation and neuroblast differentiation in the dentate gyrus. BME was administered to 7-week-old mice once a day for 4 weeks and a novel object recognition memory test was performed. Thereafter, the mice were euthanized followed by immunohistochemistry analysis for Ki67, doublecortin (DCX), and phosphorylated cAMP response elementbinding protein (CREB), and western blot analysis of brain-derived neurotrophic factor (BDNF). BMEtreated mice showed moderate increases in the exploration of new objects when compared with that of familiar objects, leading to a significant higher discrimination index compared with vehicle-treated mice. Ki67 and DCX immunohistochemistry showed a facilitation of cell proliferation and neuroblast differentiation following the administration of BME in the dentate gyrus. In addition, administration of BME significantly elevated the BDNF protein expression in the hippocampal dentate gyrus, and in creased CREB phosphorylation in the dentate gyrus. These data suggest that BME improves novel object recognition by increasing the cell proliferation and neuroblast differentiation in the dentate gyrus, and this may be closely related to elevated levels of BDNF and CREB phosphorylation in the dentate gyrus.
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