Cardamonin Inhibits the Expression of Inducible Nitric Oxide Synthase Induced by TLR2, 4, and 6 AgonistsCardamonin Inhibits the Expression of Inducible Nitric Oxide Synthase Induced by TLR2, 4, and 6 Agonists
- Other Titles
- Cardamonin Inhibits the Expression of Inducible Nitric Oxide Synthase Induced by TLR2, 4, and 6 Agonists
- Authors
- 김아연; 심현진; 김수연; 허성혜; 윤형선
- Issue Date
- 2018
- Publisher
- 대한의생명과학회
- Keywords
- Cardamonin; Inducible nitric oxide synthase; TLR; Inflammation; LPS
- Citation
- 대한의생명과학회지, v.24, no.2, pp.102 - 107
- Journal Title
- 대한의생명과학회지
- Volume
- 24
- Number
- 2
- Start Page
- 102
- End Page
- 107
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/6657
- DOI
- 10.15616/BSL.2018.24.2.102
- Abstract
- Toll-like receptors (TLRs) play an important role for host defense against invading pathogens. The activation of TLRs signaling leads to the activation of NF-κB and the expression of pro-inflammatory gene products such as cytokines and inducible nitric oxide synthase (iNOS). To evaluate the therapeutic potential of cardamonin, which is a naturally occurring chalcone from Alpinia species (zingiberaceous plant species), NF-κB activation and iNOS expression induced by MALP-2 (TLR2 and TLR6 agonist) or LPS (TLR4 agonist) were examined. Cardamonin inhibited the activation of NF-κB induced by MALP-2 or LPS. Cardamonin also suppressed the iNOS expression induced by MALP-2 or LPS. These results suggest that cardamonin has the specific mechanism for anti-inflammatory responses by regulating of TLRs signaling pathway.
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Collections - College of Medical Sciences > Department of Biomedical Laboratory Science > 1. Journal Articles
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