Therapeutic Approaches to Atrophic Vaginitis in Postmenopausal Women: A Systematic Review with a Network Meta-analysis of Randomized Controlled TrialsTherapeutic Approaches to Atrophic Vaginitis in Postmenopausal Women: A Systematic Review with a Network Meta-analysis of Randomized Controlled Trials
- Other Titles
- Therapeutic Approaches to Atrophic Vaginitis in Postmenopausal Women: A Systematic Review with a Network Meta-analysis of Randomized Controlled Trials
- Authors
- Arum Lee; 김태희; 이해혁; Yeon-Suk Kim; Temuulee Enkhbold; Bora Lee; Yoo Jin Park; Kisung Song
- Issue Date
- 2018
- Publisher
- 대한폐경학회
- Keywords
- Atrophic vaginitis; Network meta-analysis; Postmenopause; Therapeutics; Vagina
- Citation
- 대한폐경학회지, v.24, no.1, pp 1 - 10
- Pages
- 10
- Journal Title
- 대한폐경학회지
- Volume
- 24
- Number
- 1
- Start Page
- 1
- End Page
- 10
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/6704
- ISSN
- 2288-6478
2288-6761
- Abstract
- Objectives: Atrophic vaginitis (AV), which is common in postmenopausal women, is characterized by vaginal dryness, dyspareunia, and discomfort. There are a variety of therapeutic agents for the treatment of AV, besides hormone replacement therapy. We performed this systematic review to compare the effectiveness of various therapies for symptom improvement in AV patients.
Methods: We searched the Cochrane Library, EMBASE, MEDLINE, and other literature (Google Scholar, Web of Science, and hand search) for studies published between January 2010 and March 2015. AV was evaluated by the following outcomes: vaginal pH, dyspareunia, vaginal dryness, or cytological change (endometrial thickness, percentages of superficial cells and parabasal cells).
They measured treatment efficacy with various outcomes pertaining to AV symptoms.
Results: Meta-analysis suggested that ospemifene was effective against dyspareunia, vaginal dryness, endometrial thickness, and percentage changes in superficial and parabasal cells. Vaginal pH was most affected by soy isoflavone vaginal gel. Ospemifene was effective for AV symptoms.
Conclusions: This systematic review compared the effects of several therapeutic agents on symptoms of AV through a network meta-analysis. This study provides objective evidence for clinical treatment and efficacy management in AV. (J Menopausal Med 2018;24:1-10)
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Collections - College of Medicine > Department of Obstetrics and Gynecology > 1. Journal Articles
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