Microfluidic multiplexing of solid-state nanopores
- Authors
- Jain, Tarun; Rasera, Benjamin C.; Guerrero, Ricardo Jose S.; Lim, Jong-Min; Karnik, Rohit
- Issue Date
- 6-Dec-2017
- Publisher
- Institute of Physics Publishing
- Keywords
- nanopore; integration; microfluidics; parallel; multichannel; resistive-pulse sensing
- Citation
- Journal of Physics: Condensed Matter, v.29, no.48
- Journal Title
- Journal of Physics: Condensed Matter
- Volume
- 29
- Number
- 48
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/6904
- DOI
- 10.1088/1361-648X/aa9455
- ISSN
- 0953-8984
1361-648X
- Abstract
- Although solid-state nanopores enable electronic analysis of many clinically and biologically relevant molecular structures, there are few existing device architectures that enable high-throughput measurement of solid-state nanopores. Herein, we report, a method for microfluidic integration of multiple solid-state nanopores at a high density of one nanopore per (35 mu m(2)). By configuring microfluidic devices with microfluidic valves, the nanopores can be rinsed from a single fluid input while retaining compatibility for multichannel electrical measurements. The microfluidic valves serve the dual purpose of fluidic switching and electric switching, enabling serial multiplexing of the eight nanopores with a single pair of electrodes. Furthermore, the device architecture exhibits low noise and is compatible with electroporation-based in situ nanopore fabrication, providing a scalable platform for automated electronic measurement of a large number of integrated solid-state nanopores.
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Collections - College of Engineering > Department of Chemical Engineering > 1. Journal Articles
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