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Clinical Characteristics of Exacerbation-Prone Adult Asthmatics Identified by Cluster Analysis

Authors
Kim, Mi-AeShin, Seung-WooPark, Jong-SookUh, Soo-TaekChang, Hun SooBae, Da-JeongCho, You SookPark, Hae-SimYoon, Ho JooChoi, Byoung WhuiKim, Yong HoonPark, Choon-Sik
Issue Date
Nov-2017
Publisher
대한천식알레르기학회
Keywords
Asthma; cluster analysis; exacerbation
Citation
Allergy, Asthma & Immunology Research, v.9, no.6, pp 483 - 490
Pages
8
Journal Title
Allergy, Asthma & Immunology Research
Volume
9
Number
6
Start Page
483
End Page
490
URI
https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7075
DOI
10.4168/aair.2017.9.6.483
ISSN
2092-7355
2092-7363
Abstract
Purpose: Asthma is a heterogeneous disease characterized by various types of airway inflammation and obstruction. Therefore, it is classified into several subphenotypes, such as early-onset atopic, obese non-eosinophilic, benign, and eosinophilic asthma, using cluster analysis. A number of asthmatics frequently experience exacerbation over a long-term follow-up period, but the exacerbation-prone subphenotype has rarely been evaluated by cluster analysis. This prompted us to identify clusters reflecting asthma exacerbation. Methods: A uniform cluster analysis method was applied to 259 adult asthmatics who were regularly followed-up for over 1 year using 12 variables, selected on the basis of their contribution to asthma phenotypes. After clustering, clinical profiles and exacerbation rates during follow-up were compared among the clusters. Results: Four subphenotypes were identified: cluster 1 was comprised of patients with early-onset atopic asthma with preserved lung function, cluster 2 late-onset non-atopic asthma with impaired lung function, cluster 3 early-onset atopic asthma with severely impaired lung function, and cluster 4 late-onset non-atopic asthma with well-preserved lung function. The patients in clusters 2 and 3 were identified as exacerbation-prone asthmatics, showing a higher risk of asthma exacerbation. Conclusions: Two different phenotypes of exacerbation-prone asthma were identified among Korean asthmatics using cluster analysis; both were characterized by impaired lung function, but the age at asthma onset and atopic status were different between the two.
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College of Medicine > Department of Internal Medicine > 1. Journal Articles
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College of Medicine > Department of Internal Medicine > 1. Journal Articles

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