Phase-contrast hard X-ray microscopy using synchrotron radiation for the properties of skeletal muscle in mouse hind limbs
- Authors
- Jang, Sanghun; Lim, Jaehong; Lee, Onseok
- Issue Date
- Nov-2017
- Publisher
- John Wiley & Sons Inc.
- Keywords
- phase-contrast X-ray; skeletal muscle; soleus; synchrotron
- Citation
- Microscopy Research and Technique, v.80, no.11, pp 1221 - 1228
- Pages
- 8
- Journal Title
- Microscopy Research and Technique
- Volume
- 80
- Number
- 11
- Start Page
- 1221
- End Page
- 1228
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7087
- DOI
- 10.1002/jemt.22920
- ISSN
- 1059-910X
1097-0029
- Abstract
- Radiation beam interface contrast X-ray microscopy provides resolution of a few dozen nanometers from fixed whole muscle biopsies, allowing better reconstruction of the microstructure of the muscle than is currently possible with classic histological techniques. Fixed soleus muscle biopsies have been evaluated from the walk-in mouse model using phase-contrast X-ray microscopy, and results presented that corroborate the accuracy of the method used, and its potential for application in physiotherapy and occupational therapy studies. We believe that this method will enhance existing morphometric methods of analysis, leading to accurate reconstruction of other thick specimens that would otherwise require thin sectioning and reconstruction through deconvolution algorithms.
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- Appears in
Collections - College of Medical Sciences > Department of Medical IT Engineering > 1. Journal Articles
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