Capsule, septum, and T2 hyperintense foci for differentiation between large hepatocellular carcinoma (>= 5 cm) and intrahepatic cholangiocarcinoma on gadoxetic acid MRI
- Authors
- Hwang, Jiyoung; Kim, Young Kon; Min, Ji Hye; Choi, Seo-Youn; Jeong, Woo Kyung; Hong, Seong Sook; Kim, Hyun-joo; Ahn, Soohyun; Ahn, Hyeon Seon
- Issue Date
- Nov-2017
- Publisher
- Springer Verlag
- Keywords
- Gadoxetic acid; MRI; Hepatocellular carcinoma; Cholangiocarcinoma; Ancillary feature
- Citation
- European Radiology, v.27, no.11, pp 4581 - 4590
- Pages
- 10
- Journal Title
- European Radiology
- Volume
- 27
- Number
- 11
- Start Page
- 4581
- End Page
- 4590
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7090
- DOI
- 10.1007/s00330-017-4846-4
- ISSN
- 0938-7994
1432-1084
- Abstract
- Objective To determine the added value of capsule, septum, and T2 hyperintense foci for differentiating large hepatocellular carcinoma (HCC; >= 5 cm) from intrahepatic cholangiocarcinoma (ICC) using gadoxetic acid MRI. Methods The study included 116 patients (94 men, 22 women; mean age, 56.8 years) with surgically confirmed HCCs (n = 87, 5.0-18.0 cm) or ICCs (n = 29, 5.0-14.0 cm) who underwent gadoxetic acid MRI. Three observers independently reviewed MRIs in two sessions, examining enhancement patterns only and then adding capsule, septum, and T2 hyperintense foci. Reviewers used a five-point scale to score accuracy, sensitivity, and specificity. Results A significant increase was observed in accuracy when ancillary features (96.1-98.3%) were added compared to enhancement pattern only (83.6-88.4%; p ae<currency> 0.02). Sensitivity was significantly increased with combined reading (97.1-98.3%) compared to enhancement features only (81.6-88.5%; p ae<currency> 0.006) for two observers, with no difference in specificity (84.5-89.7% vs. 86.2-98.3%; p > 0.05). We found substantial to excellent interobserver agreement for ancillary features (0.598-0.976). Conclusion Adding capsule, septum, and T2 hyperintense foci to enhancement patterns for gadoxetic acid MRI increased diagnostic performance for characterizing large HCC by differentiating it from ICC.
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Collections - College of Medicine > Department of Radiology > 1. Journal Articles
- College of Medicine > Department of Radiology > 1. Journal Articles
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