In vitro activity of alpha-viniferin isolated from the roots of Carex humilis against Mycobacterium tuberculosis
- Authors
- Seo, Hoonhee; Kim, Mijung; Kim, Sukyung; Al Mahmud, Hafij; Islam, Md Imtiazul; Nam, Kung-Woo; Cho, Myoung-Lae; Kwon, Hyun-Sook; Song, Ho-Yeon
- Issue Date
- Oct-2017
- Publisher
- Academic Press
- Keywords
- Mycobacterium tuberculosis; alpha-Viniferin; Carex humilis; XDR; MRSA
- Citation
- Pulmonary Pharmacology and Therapeutics, v.46, pp 41 - 47
- Pages
- 7
- Journal Title
- Pulmonary Pharmacology and Therapeutics
- Volume
- 46
- Start Page
- 41
- End Page
- 47
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7154
- DOI
- 10.1016/j.pupt.2017.08.003
- ISSN
- 1094-5539
1522-9629
- Abstract
- This study explores the antitubercular activity of alpha-viniferin, a bioactive phytochemical compound obtained from Carex humilis. alpha-Viniferin was active against both drug-susceptible and -resistant strains of Mycobacterium tuberculosis at MIC(50)s of 4.6 mu M in culture broth medium and MIC(50)s of 2.3-4.6 mu M inside macrophages and pneumocytes. In combination with streptomycin and ethambutol, alpha-viniferin exhibited an additive effect and partial synergy, respectively, against M. tuberculosis H37Rv. alpha-Viniferin also did not show cytotoxicity in any of the cell lines tested up to a concentration of 147 M, which gives this compound a selectivity index of >32. Moreover, alpha-viniferin was active against 3 Staphylococcus species, including methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant Staphylococcus aureus (MRSA), and methicillin-resistant Staphylococcus epidermidis (MRSE). (C) 2017 Elsevier Ltd. All rights reserved.
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Collections - College of Medicine > Department of Microbiology > 1. Journal Articles
- College of Natural Sciences > Department of Biology > 1. Journal Articles
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