Frontline treatment with chemoimmunotherapy for limited-stage ocular adnexal MALT lymphoma with adverse factors: a phase II study
- Authors
- Kim, Sung-Yong; Yang, Suk-Woo; Lee, Won-Sik; Yang, Jae Wook; Oh, Sung Yong; Ahn, Hee Bae; Yang, Deok-Hwan; Park, Seong Kyu; Chang, Jee Ho; Kim, Hyo Jung; Lee, Min Joung; Cho, Seok-Goo
- Issue Date
- 15-Sep-2017
- Publisher
- Impact Journals
- Keywords
- lymphoma; ocular; mucosa associated lymphoid tissue; rituximab; chemoimmunotherapy
- Citation
- Oncotarget, v.8, no.40, pp 68583 - 68590
- Pages
- 8
- Journal Title
- Oncotarget
- Volume
- 8
- Number
- 40
- Start Page
- 68583
- End Page
- 68590
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7209
- ISSN
- 1949-2553
- Abstract
- Background: Radiotherapy is a commonly used treatment for limited-stage ocular adnexal mucosa-associated lymphoid tissue lymphoma (OAML) but showed a substantial relapse risk if the disease involves beyond-conjunctiva or bilateral conjunctivae. Systemic chemoimmunotherapy may be an alternative frontline therapy for the limited disease with those adverse prognostic factors. Patients and methods: We designed a multicenter, phase II study of the chemoimmunotherapy, rituximab, cyclophosphamide, vincristine, and prednisolone (R-CVP) for the treatment of patients with limited-stage OAML with bilateral or beyond-conjunctival involvement. Thirty-three patients with Ann Arbor stage I OAML with the adverse factors were enrolled. Patients received six cycles of R-CVP followed by two cycles of rituximab therapy. Results: At the end of treatment, all the enrolled patients had responded. The cumulative complete response achievement was 93.9% at 2 years. At a median follow-up of 50.6 months, three patients had progressed. Progression-free survival and overall survival at 4 years was 90.3 +/- 5.3% and 100%, respectively. Conclusions: This phase II study demonstrated durable efficacy of R-CVP chemoimmunotherapy, which has promise as an alternative frontline therapy for the limited-stage OAML patients with adverse prognostic factors.
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Collections - College of Medicine > Department of Ophthalmology > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
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