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Plant-derived oxidized nanofibrillar cellulose-chitosan composite as an absorbable hemostat
- Authors
- Sukul, Mousumi; Ventura, Reiza D.; Bae, Sang Ho; Choi, Hwan Jun; Lee, Sun Young; Lee, Byong Taek
- Issue Date
- 15-Jun-2017
- Publisher
- Elsevier BV
- Keywords
- Absorbable hemostat; Oxidized nanofibrillar cellulose; Chitosan
- Citation
- Materials Letters, v.197, pp 150 - 155
- Pages
- 6
- Journal Title
- Materials Letters
- Volume
- 197
- Start Page
- 150
- End Page
- 155
- ISSN
- 0167-577X
1873-4979
- Abstract
- In this study, a new absorbable hemostat was developed with two most abundantly found natural polymers. Oxidized nanofibrillar cellulose (ONFC)-chitosan (Ch) sponge was prepared by lyophilization at a volume ratio of 50:50. Cytotoxicity and cell proliferation studies revealed that the sponge was noncytotoxic and the cell proliferated continuously on the sponge. ONFC-Ch sponge showed better hemostatic effect on hepatic trauma than ONFC sponge. Both sponges were implanted on hepatic trauma for 1 and 3 weeks. ONFC-Ch sponge showed greater degree biodegradability and biocompatibility. Thus, ONFC-Ch sponge can be considered as a potential hemostatic material. (C) 2017 Elsevier B.V. All rights reserved.
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Related Researcher
- Lee, Byong Taek
- College of Medicine (Department of Regenerative Medicine)