The relationship of 19 functional polymorphisms in iodothyronine deiodinase and psychological well-being in hypothyroid patients
DC Field | Value | Language |
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dc.contributor.author | Cho, Yoon Young | - |
dc.contributor.author | Kim, Hye Jeong | - |
dc.contributor.author | Jang, Hye Won | - |
dc.contributor.author | Kim, Tae Hyuk | - |
dc.contributor.author | Ki, Chang-Seok | - |
dc.contributor.author | Kim, Sun Wook | - |
dc.contributor.author | Chung, Jae Hoon | - |
dc.date.accessioned | 2021-08-11T14:44:24Z | - |
dc.date.available | 2021-08-11T14:44:24Z | - |
dc.date.issued | 2017-06 | - |
dc.identifier.issn | 1355-008x | - |
dc.identifier.issn | 1559-0100 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7539 | - |
dc.description.abstract | Levothyroxine supplementation is insufficient for the management of one tenth of patients with hypothyroidism. Iodothyronine deiodinases have been suggested to play a role in residual hypothyroid symptoms of these patients by controlling local thyroid hormone homeostasis. Previous research has suggested a relationship between commonly inherited variations in type 2 iodothyronine deiodinase and impaired well-being. We evaluated the prevalence of iodothyronine deiodinase genotypes and their association with psychological well-being in the Korean hypothyroid population. A prospective observational study. We enrolled 196 hypothyroid subjects (136 chronic autoimmune thyroiditis and 60 thyroid cancer) and assessed baseline well-being using six validated questionnaires. Genotyping was conducted for 19 single nucleotide polymorphisms in type 1, 2, and 3 iodothyronine deiodinase using Sequenom MassARRAY matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in all patients. Frequencies of iodothyronine deiodinase genotypes and well-being scores were not different in hypothyroid subjects according to their disease types. Minor genotypes of a few iodothyronine deiodinase 1 variants (rs11206244, rs2294512, and rs4926616) were associated with reduced psychological well-being. However, iodothyronine deiodinase 2 and 3 variants had no effect on baseline well-being. Minor variations in iodothyronine deiodinase 1 were associated with decreased well-being in the Korean hypothyroid population, whereas iodothyronine deiodinase 2 and 3 were not. Due to controversial results among different ethnicities, further studies to clarify the effects of iodothyronine deiodinase polymorphisms on psychological well-being are warranted in hypothyroid individuals. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Macmillan Publishers | - |
dc.title | The relationship of 19 functional polymorphisms in iodothyronine deiodinase and psychological well-being in hypothyroid patients | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1007/s12020-017-1307-4 | - |
dc.identifier.scopusid | 2-s2.0-85018426011 | - |
dc.identifier.wosid | 000403670300015 | - |
dc.identifier.bibliographicCitation | Endocrine, v.57, no.1, pp 115 - 124 | - |
dc.citation.title | Endocrine | - |
dc.citation.volume | 57 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 115 | - |
dc.citation.endPage | 124 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | THYROXINE PLUS TRIIODOTHYRONINE | - |
dc.subject.keywordPlus | QUALITY-OF-LIFE | - |
dc.subject.keywordPlus | TYPE-2 DEIODINASE | - |
dc.subject.keywordPlus | THR92ALA POLYMORPHISM | - |
dc.subject.keywordPlus | COMMON VARIATION | - |
dc.subject.keywordPlus | KOREAN VERSION | - |
dc.subject.keywordPlus | TASK-FORCE | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordAuthor | Iodothyronine deiodinase | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Hypothyroidism | - |
dc.subject.keywordAuthor | Psychological well-being | - |
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