The relationship of 19 functional polymorphisms in iodothyronine deiodinase and psychological well-being in hypothyroid patients
- Authors
- Cho, Yoon Young; Kim, Hye Jeong; Jang, Hye Won; Kim, Tae Hyuk; Ki, Chang-Seok; Kim, Sun Wook; Chung, Jae Hoon
- Issue Date
- Jun-2017
- Publisher
- Macmillan Publishers
- Keywords
- Iodothyronine deiodinase; Polymorphism; Hypothyroidism; Psychological well-being
- Citation
- Endocrine, v.57, no.1, pp 115 - 124
- Pages
- 10
- Journal Title
- Endocrine
- Volume
- 57
- Number
- 1
- Start Page
- 115
- End Page
- 124
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7539
- DOI
- 10.1007/s12020-017-1307-4
- ISSN
- 1355-008x
1559-0100
- Abstract
- Levothyroxine supplementation is insufficient for the management of one tenth of patients with hypothyroidism. Iodothyronine deiodinases have been suggested to play a role in residual hypothyroid symptoms of these patients by controlling local thyroid hormone homeostasis. Previous research has suggested a relationship between commonly inherited variations in type 2 iodothyronine deiodinase and impaired well-being. We evaluated the prevalence of iodothyronine deiodinase genotypes and their association with psychological well-being in the Korean hypothyroid population. A prospective observational study. We enrolled 196 hypothyroid subjects (136 chronic autoimmune thyroiditis and 60 thyroid cancer) and assessed baseline well-being using six validated questionnaires. Genotyping was conducted for 19 single nucleotide polymorphisms in type 1, 2, and 3 iodothyronine deiodinase using Sequenom MassARRAY matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in all patients. Frequencies of iodothyronine deiodinase genotypes and well-being scores were not different in hypothyroid subjects according to their disease types. Minor genotypes of a few iodothyronine deiodinase 1 variants (rs11206244, rs2294512, and rs4926616) were associated with reduced psychological well-being. However, iodothyronine deiodinase 2 and 3 variants had no effect on baseline well-being. Minor variations in iodothyronine deiodinase 1 were associated with decreased well-being in the Korean hypothyroid population, whereas iodothyronine deiodinase 2 and 3 were not. Due to controversial results among different ethnicities, further studies to clarify the effects of iodothyronine deiodinase polymorphisms on psychological well-being are warranted in hypothyroid individuals.
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