Tailoring pharmacotherapy for male lower urinary tract symptoms: A prospective, multicenter, observational trial
DC Field | Value | Language |
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dc.contributor.author | Sung, Hyun Hwan | - |
dc.contributor.author | Ko, Kwang Jin | - |
dc.contributor.author | Suh, Yoon Seok | - |
dc.contributor.author | Kim, Joon Chul | - |
dc.contributor.author | Choi, Jong Bo | - |
dc.contributor.author | Song, Yun-Seob | - |
dc.contributor.author | Lee, Kyu-Sung | - |
dc.date.accessioned | 2021-08-11T14:44:32Z | - |
dc.date.available | 2021-08-11T14:44:32Z | - |
dc.date.issued | 2017-05 | - |
dc.identifier.issn | 1368-5031 | - |
dc.identifier.issn | 1742-1241 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7582 | - |
dc.description.abstract | Objectives: The aim of this study was to evaluate the pattern of tailoring and efficacy of several types of pharmacotherapy in male LUTS. Methods: Prospectively 404 male subjects were included who were over 40 years old, had at least 3 months symptom duration, and 12 or higher international prostate symptom score (IPSS). Subjects were treated with several types of pharmacotherapy for 6 months and were evaluated with IPSS/QoL at every follow-up. Subjects were subdivided into storage (44%), nocturia (18.5%), and voiding symptom (37.5%) groups according to the most bothersome symptom. Results: At 6 months, 188 subjects (46.5%) completed the study. The mean age was 64.2 +/- 8.5 years, and symptom duration was 30.6 +/- 32.6 months. PSA was 2.98 +/- 7.96 ng/mL, and prostate size was 32.8 +/- 14.2 cc. IPSS continually decreased from baseline (18.7) to last follow-up (10.8). Combination therapy increased from 33.0% to 52.7% at last follow-up (P=.006). However, there was no difference of IPSS changes between combination and monotherapy groups (P>.05). Only antimuscarinic prescription significantly increased from 15.4% to 28.2% (P=.004). Mean number of visits to the clinic was 3.6 +/- 1.3 and the number of treatment changes was 0.31 +/- 0.47. The nocturia (0.47 +/- 0.51) group changed treatment more than voiding group (0.21 +/- 0.41, P=.003). However, the voiding group (-9.4) had significantly more improvement than e storage (-6.4) and nocturia (-7.8) groups (P=.011). Conclusions: Male LUTS continually improved over 6 months with customised treatment. Pharmacotherapy for male LUTS should be tailored by symptom type and alteration of symptoms during treatment. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Medicom International, Inc. | - |
dc.title | Tailoring pharmacotherapy for male lower urinary tract symptoms: A prospective, multicenter, observational trial | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1111/ijcp.12947 | - |
dc.identifier.scopusid | 2-s2.0-85019247935 | - |
dc.identifier.wosid | 000404545000009 | - |
dc.identifier.bibliographicCitation | International Journal of Clinical Practice, v.71, no.5 | - |
dc.citation.title | International Journal of Clinical Practice | - |
dc.citation.volume | 71 | - |
dc.citation.number | 5 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | BENIGN-PROSTATIC-HYPERPLASIA | - |
dc.subject.keywordPlus | QUALITY-OF-LIFE | - |
dc.subject.keywordPlus | OVERACTIVE BLADDER | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | MEN | - |
dc.subject.keywordPlus | NOCTURIA | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | OBSTRUCTION | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordAuthor | Pharmacotherapy | - |
dc.subject.keywordAuthor | prostate | - |
dc.subject.keywordAuthor | lower urinary tractsymptoms | - |
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