Tailoring pharmacotherapy for male lower urinary tract symptoms: A prospective, multicenter, observational trial
- Authors
- Sung, Hyun Hwan; Ko, Kwang Jin; Suh, Yoon Seok; Kim, Joon Chul; Choi, Jong Bo; Song, Yun-Seob; Lee, Kyu-Sung
- Issue Date
- May-2017
- Publisher
- Medicom International, Inc.
- Keywords
- Pharmacotherapy; prostate; lower urinary tractsymptoms
- Citation
- International Journal of Clinical Practice, v.71, no.5
- Journal Title
- International Journal of Clinical Practice
- Volume
- 71
- Number
- 5
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7582
- DOI
- 10.1111/ijcp.12947
- ISSN
- 1368-5031
1742-1241
- Abstract
- Objectives: The aim of this study was to evaluate the pattern of tailoring and efficacy of several types of pharmacotherapy in male LUTS. Methods: Prospectively 404 male subjects were included who were over 40 years old, had at least 3 months symptom duration, and 12 or higher international prostate symptom score (IPSS). Subjects were treated with several types of pharmacotherapy for 6 months and were evaluated with IPSS/QoL at every follow-up. Subjects were subdivided into storage (44%), nocturia (18.5%), and voiding symptom (37.5%) groups according to the most bothersome symptom. Results: At 6 months, 188 subjects (46.5%) completed the study. The mean age was 64.2 +/- 8.5 years, and symptom duration was 30.6 +/- 32.6 months. PSA was 2.98 +/- 7.96 ng/mL, and prostate size was 32.8 +/- 14.2 cc. IPSS continually decreased from baseline (18.7) to last follow-up (10.8). Combination therapy increased from 33.0% to 52.7% at last follow-up (P=.006). However, there was no difference of IPSS changes between combination and monotherapy groups (P>.05). Only antimuscarinic prescription significantly increased from 15.4% to 28.2% (P=.004). Mean number of visits to the clinic was 3.6 +/- 1.3 and the number of treatment changes was 0.31 +/- 0.47. The nocturia (0.47 +/- 0.51) group changed treatment more than voiding group (0.21 +/- 0.41, P=.003). However, the voiding group (-9.4) had significantly more improvement than e storage (-6.4) and nocturia (-7.8) groups (P=.011). Conclusions: Male LUTS continually improved over 6 months with customised treatment. Pharmacotherapy for male LUTS should be tailored by symptom type and alteration of symptoms during treatment.
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Collections - College of Medicine > Department of Urology > 1. Journal Articles
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