Clinical Characteristics and Treatment Outcome of Peginterferon Plus Ribavirin in Patients Infected with Genotype 6 Hepatitis C Virus in Korea: A Multicenter Study
- Authors
- Shin, Su Rin; Kim, Young Seok; Lim, Young-Seok; Lee, June Sung; Lee, Jin Woo; Kim, Sun Myung; Jeong, Sook-Hyang; Sohn, Joo Hyun; Lee, Myung Seok; Park, Sang Hoon
- Issue Date
- Mar-2017
- Publisher
- 거트앤리버 발행위원회
- Keywords
- Hepatitis C; chronic; Genotype 6; Peginterferon alfa; Ribavirin
- Citation
- Gut and Liver, v.11, no.2, pp 270 - 275
- Pages
- 6
- Journal Title
- Gut and Liver
- Volume
- 11
- Number
- 2
- Start Page
- 270
- End Page
- 275
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7763
- DOI
- 10.5009/gnl16163
- ISSN
- 1976-2283
2005-1212
- Abstract
- Background/Aims: Because of the limited geographic distribution, there have been insufficient data regarding hepatitis C virus (HCV) genotype 6 in Korea. This study aimed to investigate the clinical characteristics and available treatment outcomes of patients with genotype 6 HCV in Korea. Methods: From 2004 to 2014, data were collected from Korean patients infected with genotype 6 HCV in eight hospitals. Results: Thirty-two patients had genotype 6 HCV. The median age was 44 years, and 6c was the most common subtype. The baseline median alanine transaminase level was 88 (21 to 1,019) IU/mL, and the HCV RNA level was 1,405,000 (96,500 to 28,844,529) IU/mL. Twenty-five patients were treated with peginterferon (PEG-IFN) and ribavirin. Three follow-up losses occurred. Additionally, 13 patients attained a sustained virologic response (SVR), seven patients relapsed, and two patients exhibited a null response. The SVR rates were 40% and 75% for the 24- and more than 48 week treatments, respectively, and five of the six patients who achieved a rapid virologic response (RVR) attained a SVR. Conclusions: Korean patients infected with genotype 6 HCV are relatively young, and 6c is the most common subtype. When treated with PEG-IFN and ribavirin, the SVR rate was 52%. Similar to other genotypes, a longer duration of treatment and attainment of RVR are important for SVR.
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