Upregulation of interleukin-33 and thymic stromal lymphopoietin levels in the lungs of idiopathic pulmonary fibrosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jong-Uk | - |
dc.contributor.author | Chang, Hun Soo | - |
dc.contributor.author | Lee, Hyeon Ju | - |
dc.contributor.author | Jung, Chang An | - |
dc.contributor.author | Bae, Da Jeong | - |
dc.contributor.author | Song, Hyun Ji | - |
dc.contributor.author | Park, Jong Sook | - |
dc.contributor.author | Uh, Soo-Taek | - |
dc.contributor.author | Kim, Young Hoon | - |
dc.contributor.author | Seo, Ki-Hyun | - |
dc.contributor.author | Park, Choon-Sik | - |
dc.date.accessioned | 2021-08-11T15:24:24Z | - |
dc.date.available | 2021-08-11T15:24:24Z | - |
dc.date.issued | 2017-02-15 | - |
dc.identifier.issn | 1471-2466 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7783 | - |
dc.description.abstract | Background: Innate T helper type 2 (Th2) immune responses mediated by interleukin (IL)-33, thymic stromal lymphopoietin (TSLP), and IL-25 have been shown to play an important role in pulmonary fibrosis of animal models; however, their clinical implications remain poorly understood. Methods: TSLP, IL-25, and IL-33 concentrations were measured in bronchoalveolar lavage fluids obtained from normal controls (NCs; n = 40) and from patients with idiopathic pulmonary fibrosis (IPF; n = 100), non-specific interstitial pneumonia (NSIP; n = 22), hypersensitivity pneumonitis (HP; n = 20), and sarcoidosis (n = 19). Results: The TSLP and IL-33 levels were significantly higher in patients with IPF relative to the NCs (p = 0.01 and p = 0.0001, respectively), NSIP (p = 4.95E -7 and p = 0.0002, respectively), HP (p = 0.00003 and p = 0.000005, respectively), and sarcoidosis groups (p = 0.003 and p = 0.0001, respectively). However, the IL-25 levels were not significantly different between NC and IPF group (p = 0.432). Receiver operating characteristic curves of the TSLP and IL-33 levels revealed clear differences between the IPF and NC groups (AUC = 0.655 and 0.706, respectively), as well as between the IPF and the other lung disease groups (AUC = 0.786 and 0.781, respectively). Cut-off values of 3.52 pg/mu g TSLP and 3.77 pg/mu g IL-33 were shown to differentiate between the IPF and NC groups with 99.2 and 94.3% accuracy. Cut-off values of 4.66 pg/mu g TSLP and 2.52 pg/mu g IL-33 possessed 99.4 and 93.2% accuracy for differentiating among the IPF and other interstitial lung disease groups. Conclusions: Innate immune responses may be associated with the development of IPF. Furthermore, the IL-33 and TSLP levels in BAL fluids may be useful for differentiating IPF from other chronic interstitial lung diseases. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | BioMed Central | - |
dc.title | Upregulation of interleukin-33 and thymic stromal lymphopoietin levels in the lungs of idiopathic pulmonary fibrosis | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1186/s12890-017-0380-z | - |
dc.identifier.scopusid | 2-s2.0-85013213855 | - |
dc.identifier.wosid | 000394823800001 | - |
dc.identifier.bibliographicCitation | BMC Pulmonary Medicine, v.17 | - |
dc.citation.title | BMC Pulmonary Medicine | - |
dc.citation.volume | 17 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.subject.keywordPlus | INNATE LYMPHOID-CELLS | - |
dc.subject.keywordPlus | INTERSTITIAL PNEUMONIA | - |
dc.subject.keywordPlus | IL-33 | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ASTHMA | - |
dc.subject.keywordPlus | IL-25 | - |
dc.subject.keywordPlus | TSLP | - |
dc.subject.keywordPlus | FIBROBLASTS | - |
dc.subject.keywordPlus | PROFILES | - |
dc.subject.keywordAuthor | IL-25 | - |
dc.subject.keywordAuthor | IL-33 | - |
dc.subject.keywordAuthor | TSLP | - |
dc.subject.keywordAuthor | IPF | - |
dc.subject.keywordAuthor | Innate immune response | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.