Upregulation of interleukin-33 and thymic stromal lymphopoietin levels in the lungs of idiopathic pulmonary fibrosisopen access
- Authors
- Lee, Jong-Uk; Chang, Hun Soo; Lee, Hyeon Ju; Jung, Chang An; Bae, Da Jeong; Song, Hyun Ji; Park, Jong Sook; Uh, Soo-Taek; Kim, Young Hoon; Seo, Ki-Hyun; Park, Choon-Sik
- Issue Date
- 15-Feb-2017
- Publisher
- BioMed Central
- Keywords
- IL-25; IL-33; TSLP; IPF; Innate immune response
- Citation
- BMC Pulmonary Medicine, v.17
- Journal Title
- BMC Pulmonary Medicine
- Volume
- 17
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7783
- DOI
- 10.1186/s12890-017-0380-z
- ISSN
- 1471-2466
- Abstract
- Background: Innate T helper type 2 (Th2) immune responses mediated by interleukin (IL)-33, thymic stromal lymphopoietin (TSLP), and IL-25 have been shown to play an important role in pulmonary fibrosis of animal models; however, their clinical implications remain poorly understood. Methods: TSLP, IL-25, and IL-33 concentrations were measured in bronchoalveolar lavage fluids obtained from normal controls (NCs; n = 40) and from patients with idiopathic pulmonary fibrosis (IPF; n = 100), non-specific interstitial pneumonia (NSIP; n = 22), hypersensitivity pneumonitis (HP; n = 20), and sarcoidosis (n = 19). Results: The TSLP and IL-33 levels were significantly higher in patients with IPF relative to the NCs (p = 0.01 and p = 0.0001, respectively), NSIP (p = 4.95E -7 and p = 0.0002, respectively), HP (p = 0.00003 and p = 0.000005, respectively), and sarcoidosis groups (p = 0.003 and p = 0.0001, respectively). However, the IL-25 levels were not significantly different between NC and IPF group (p = 0.432). Receiver operating characteristic curves of the TSLP and IL-33 levels revealed clear differences between the IPF and NC groups (AUC = 0.655 and 0.706, respectively), as well as between the IPF and the other lung disease groups (AUC = 0.786 and 0.781, respectively). Cut-off values of 3.52 pg/mu g TSLP and 3.77 pg/mu g IL-33 were shown to differentiate between the IPF and NC groups with 99.2 and 94.3% accuracy. Cut-off values of 4.66 pg/mu g TSLP and 2.52 pg/mu g IL-33 possessed 99.4 and 93.2% accuracy for differentiating among the IPF and other interstitial lung disease groups. Conclusions: Innate immune responses may be associated with the development of IPF. Furthermore, the IL-33 and TSLP levels in BAL fluids may be useful for differentiating IPF from other chronic interstitial lung diseases.
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Soonchunhyang Institute of Medicine > 1. Journal Articles
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