Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer’s Disease: Methodology and Baseline Sample CharacteristicsKorean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer’s Disease: Methodology and Baseline Sample Characteristics
- Other Titles
- Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer’s Disease: Methodology and Baseline Sample Characteristics
- Authors
- 변민수; 이다현; 이준호; 최영민; 손보경; 이준영; 최효정; 백혜원; 김유경; 이윤상; 손철호; Inhee Mook-Jung; 최무림; 이유진; 이동우; 유승호; 김신겸; 김지욱; 우종인; 이동영; KBASE Research Group
- Issue Date
- 2017
- Publisher
- 대한신경정신의학회
- Keywords
- Alzheimer’s disease; Early diagnosis; Prediction; Biomarker; Prospective cohort study
- Citation
- PSYCHIATRY INVESTIGATION, v.14, no.6, pp.851 - 863
- Journal Title
- PSYCHIATRY INVESTIGATION
- Volume
- 14
- Number
- 6
- Start Page
- 851
- End Page
- 863
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/8037
- DOI
- 10.4306/pi.2017.14.6.851
- ISSN
- 1738-3684
- Abstract
- Objective: The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer’s disease (KBASE) aimed to recruit 650 individuals, aged from 20 to 90 years, to search for new biomarkers of Alzheimer’s disease (AD) and to investigate how multi-faceted lifetime experiences and bodily changes contribute to the brain changes or brain pathologies related to the AD process.
Methods: All participants received comprehensive clinical and neuropsychological evaluations, multi-modal brain imaging, including magnetic resonance imaging, magnetic resonance angiography, [11C]Pittsburgh compound B-positron emission tomography (PET), and [18F]fluorodeoxyglucose-PET, blood and genetic marker analyses at baseline, and a subset of participants underwent actigraph monitoring and completed a sleep diary. Participants are to be followed annually with clinical and neuropsychological assessments, and biannually with the full KBASE assessment, including neuroimaging and laboratory tests.
Results: As of March 2017, in total, 758 individuals had volunteered for this study. Among them, in total, 591 participants–291 cognitively normal (CN) old-aged individuals, 74 CN young- and middle-aged individuals, 139 individuals with mild cognitive impairment (MCI), and 87 individuals with AD dementia (ADD)–were enrolled at baseline, after excluding 162 individuals. A subset of participants (n=275) underwent actigraph monitoring.
Conclusion: The KBASE cohort is a prospective, longitudinal cohort study that recruited participants with a wide age range and a wide distribution of cognitive status (CN, MCI, and ADD) and it has several strengths in its design and methodologies. Details of the recruitment, study methodology, and baseline sample characteristics are described in this paper.
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