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Age-dependent differences in myelin basic protein expression in the hippocampus of young, adult and aged gerbilsAge-dependent differences in myelin basic protein expression in the hippocampus of young, adult and aged gerbils

Other Titles
Age-dependent differences in myelin basic protein expression in the hippocampus of young, adult and aged gerbils
Authors
안지현이태경박준하조정휘김인혜이재철홍성권전용환강일준이영주원무호이충현
Issue Date
2017
Publisher
한국실험동물학회
Keywords
Myelin basic protein; aging; hippocampus; gerbil
Citation
Laboratory Animal Research, v.33, no.3, pp 237 - 243
Pages
7
Journal Title
Laboratory Animal Research
Volume
33
Number
3
Start Page
237
End Page
243
URI
https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/8127
DOI
10.5625/lar.2017.33.3.237
ISSN
1738-6055
2233-7660
Abstract
Myelin degeneration is one of the characteristics of aging and degenerative diseases. This study investigated age-related alterations in expression of myelin basic protein (MBP) in the hippocampal subregions (dentate gyrus, CA2/3 and CA1 areas) of gerbils of various ages; young (1 month), adult (6 months) and aged (24 months), using western blot and immunohistochemistry. Western blot results showed tendencies of age-related reductions of MBP levels. MBP immunoreactivity was significantly decreased with age in synaptic sites of trisynaptic loops, perforant paths, mossy fibers, and Schaffer collaterals. In particular, MBP immunoreactive fibers in the dentate molecular cell layer (perforant path) was significantly reduced in adult and aged subjects. In addition, MBP immunoreactive mossy fibers in the dentate polymorphic layer and in the CA3 striatum radiatum was significantly decreased in the aged group. Furthermore, we observed similar age-related alterations in the CA1 stratum radiatum (Schaffer collaterals). However, the density of MBP immunoreactive fibers in the dentate granular cell layer and CA stratum pyramidale was decreased with aging. These findings indicate that expression of MBP is agedependent and tissue specific according to hippocampal layers.
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