Morphologic changes in the spinal cord following intrathecal palonosetron-HCl injection in ratsMorphologic changes in the spinal cord following intrathecal palonosetron-HCl injection in rats
- Other Titles
- Morphologic changes in the spinal cord following intrathecal palonosetron-HCl injection in rats
- Authors
- 유시현; 정진헌; 서용한; 최민경; 최원규; 김종분
- Issue Date
- 2017
- Publisher
- 대한마취통증의학회
- Keywords
- Microscopic; Palonosetron; Rats; Spinal injections.
- Citation
- Anesthesia and Pain Medicine, v.12, no.3, pp 224 - 229
- Pages
- 6
- Journal Title
- Anesthesia and Pain Medicine
- Volume
- 12
- Number
- 3
- Start Page
- 224
- End Page
- 229
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/8177
- ISSN
- 1975-5171
2383-7977
- Abstract
- Background: Intravenous palonosetron-HCl, a second-generation antagonist of selective serotonin type 3 (5-HT3) receptors, can prevent chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV). 5-HT3 receptors are abundant in the lower brainstem and the substantia gelatinosa of the spinal cord, which provides a theoretical rationale for neuraxial administration of 5-HT3 receptor antagonists for CINV, PONV, and opioid-induced nausea and vomiting. However, there are no reports of neuraxial administration of palonosetron-HCl. Before neuraxial administration of a drug is accepted for clinical use, its safety must be proven. This study was conducted to determine whether neuraxial administration of palonosetron-HCl produces neurologic injury.
Methods: Male Sprague-Dawley rats under general anesthesia were catheterized intrathecally and the catheter tip was advanced caudally to the L1 vertebra. After 7 days, 20 l of normal saline (N group, n = 6) or 20 l (1 g) of palonosetron-HCl (P group, n = 6) were injected intrathecally once per day for 2 weeks.
Neurotoxic changes were evaluated by light microscopy (LM) and electron microscopy (EM) of the spinal cord. Behavioral changes were also evaluated in both groups.
Results: One of the N group rats and three of the P group rats demonstrated abnormal behavior during intrathecal drug injection, but otherwise their behavior was normal. The spinal cords of the N group did not have any abnormal findings by LM or EM. The spinal cords of the P group had multiple vacuoles in the white matter by LM, especially in the dorsal funiculus, and EM revealed myelin, axonal, and mitochondrial swelling.
Conclusions: Results suggest that chronic intrathecal administration of palonosetron-HCl produced microscopic morphologic changes in the spinal cords of rats.
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