Anti-inflammatory Effects of Aster yomena Extracts by the Suppression of Inducible Nitric Oxide Synthase ExpressionAnti-inflammatory Effects of Aster yomena Extracts by the Suppression of Inducible Nitric Oxide Synthase Expression
- Other Titles
- Anti-inflammatory Effects of Aster yomena Extracts by the Suppression of Inducible Nitric Oxide Synthase Expression
- Authors
- 김아연; 신현명; 김지수; 심현진; 남궁우; 황경아; 윤형선
- Issue Date
- 2017
- Publisher
- 대한의생명과학회
- Keywords
- Aster yomena; Inducible nitric oxide synthase; Ovalbumin; LPS; Inflammation
- Citation
- 대한의생명과학회지, v.23, no.2, pp.104 - 110
- Journal Title
- 대한의생명과학회지
- Volume
- 23
- Number
- 2
- Start Page
- 104
- End Page
- 110
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/8242
- DOI
- 10.15616/BSL.2017.23.2.104
- Abstract
- Inflammation is a pathophysiological process that is known to be involved in numerous diseases. Microbial infection or tissue injury activates inflammatory responses, resulting in the induction of proinflammatory proteins including inducible nitric oxide synthase (iNOS). Aster yomena is used in traditional Korean remedies. Here, we investigated the effects of ethanol extracts of Aster yomena (EAY) on the expression of iNOS induced by ovalbumin (OVA), one of the major egg allergens, or lipopolysaccharide (LPS), a Toll-like receptor 4 agonist. EAY inhibited OVA- or LPS-induced NF-κB activation. EAY also suppressed OVA- or LPS-induced iNOS expression and nitrite production. These results suggest that EAY has the specific mechanism for anti-inflammatory responses and the potential to be developed as a potent anti-inflammatory and anti-allergic drug.
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Collections - College of Medical Sciences > Department of Biomedical Laboratory Science > 1. Journal Articles
- College of Natural Sciences > Department of Biology > 1. Journal Articles
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