Naphthofuroquinone derivatives show strong antimycobacterial activities against drug-resistant Mycobacteria
DC Field | Value | Language |
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dc.contributor.author | Jang, Woong Sik | - |
dc.contributor.author | Choi, Young-Sang | - |
dc.contributor.author | Kim, Sukyung | - |
dc.contributor.author | Jyoti, Md. Anirban | - |
dc.contributor.author | Seo, Hoonhee | - |
dc.contributor.author | Han, Juhye | - |
dc.contributor.author | Kim, Yong-Sik | - |
dc.contributor.author | Lyu, Jiwon | - |
dc.contributor.author | Nam, Kung-Woo | - |
dc.contributor.author | Lee, Byung-Eui | - |
dc.contributor.author | Lee, Kee-In | - |
dc.contributor.author | Song, Ho-Yeon | - |
dc.date.accessioned | 2021-08-11T16:24:21Z | - |
dc.date.available | 2021-08-11T16:24:21Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1120-009X | - |
dc.identifier.issn | 1973-9478 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/8406 | - |
dc.description.abstract | Tuberculosis, one of the world's major health problems, has become more serious due to the emergence of multi-drug resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis (MTB). In this study, we performed three anti-MTB assays to evaluate the anti-mycobacterial activity of naphthofuroquinone derivatives against drug-resistant MTB. Among them, methyl 5-[2-(dimethylamino) ethoxy]-7,12-dioxo-7,12-dihydrodinaphtho[1,2-b:2', 3'-d] furan-6-carboxylate (DFC2) exhibited strong anti-mycobacterial activity against MTB H37Ra, H37Rv and four drug-resistant MTB strains. The MIC of DFC2 ranged from 0.19-0.39 mu g/ml to 0.78-1.56 mu g/ml against all tested MTB strains. Moreover, DFC2 showed low cytotoxicity against fibroblast cells (L929) at concentrations 10-40-fold higher than their MICs. The IC50 value of DFC2 against L929 cells was 15.218 mu g/ml. In addition, DFC2 reduced the number of intracellular M. tuberculosis in macrophages in a dose-dependent manner. Taken together, our results indicate DFC2 to be promising new candidate agents for the treatment of tuberculosis. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Maney Publishing | - |
dc.title | Naphthofuroquinone derivatives show strong antimycobacterial activities against drug-resistant Mycobacteria | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1080/1120009X.2017.1296987 | - |
dc.identifier.scopusid | 2-s2.0-85014775253 | - |
dc.identifier.wosid | 000423162200002 | - |
dc.identifier.bibliographicCitation | Journal of Chemotherapy, v.29, no.6, pp 338 - 343 | - |
dc.citation.title | Journal of Chemotherapy | - |
dc.citation.volume | 29 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 338 | - |
dc.citation.endPage | 343 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | 1,4-NAPHTHOQUINONE DERIVATIVES | - |
dc.subject.keywordPlus | ANTITUBERCULOSIS DRUGS | - |
dc.subject.keywordPlus | DISULFIDE REDUCTASE | - |
dc.subject.keywordPlus | TUBERCULOSIS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | AGENTS | - |
dc.subject.keywordPlus | ANTIBACTERIAL | - |
dc.subject.keywordPlus | DIOSPYRIN | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | STRAINS | - |
dc.subject.keywordAuthor | Naphthofuroquinone | - |
dc.subject.keywordAuthor | Mycobacterium tuberculosis | - |
dc.subject.keywordAuthor | MDR | - |
dc.subject.keywordAuthor | XDR | - |
dc.subject.keywordAuthor | Intracellular killing activity | - |
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