Naphthofuroquinone derivatives show strong antimycobacterial activities against drug-resistant Mycobacteria
- Authors
- Jang, Woong Sik; Choi, Young-Sang; Kim, Sukyung; Jyoti, Md. Anirban; Seo, Hoonhee; Han, Juhye; Kim, Yong-Sik; Lyu, Jiwon; Nam, Kung-Woo; Lee, Byung-Eui; Lee, Kee-In; Song, Ho-Yeon
- Issue Date
- 2017
- Publisher
- Maney Publishing
- Keywords
- Naphthofuroquinone; Mycobacterium tuberculosis; MDR; XDR; Intracellular killing activity
- Citation
- Journal of Chemotherapy, v.29, no.6, pp 338 - 343
- Pages
- 6
- Journal Title
- Journal of Chemotherapy
- Volume
- 29
- Number
- 6
- Start Page
- 338
- End Page
- 343
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/8406
- DOI
- 10.1080/1120009X.2017.1296987
- ISSN
- 1120-009X
1973-9478
- Abstract
- Tuberculosis, one of the world's major health problems, has become more serious due to the emergence of multi-drug resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis (MTB). In this study, we performed three anti-MTB assays to evaluate the anti-mycobacterial activity of naphthofuroquinone derivatives against drug-resistant MTB. Among them, methyl 5-[2-(dimethylamino) ethoxy]-7,12-dioxo-7,12-dihydrodinaphtho[1,2-b:2', 3'-d] furan-6-carboxylate (DFC2) exhibited strong anti-mycobacterial activity against MTB H37Ra, H37Rv and four drug-resistant MTB strains. The MIC of DFC2 ranged from 0.19-0.39 mu g/ml to 0.78-1.56 mu g/ml against all tested MTB strains. Moreover, DFC2 showed low cytotoxicity against fibroblast cells (L929) at concentrations 10-40-fold higher than their MICs. The IC50 value of DFC2 against L929 cells was 15.218 mu g/ml. In addition, DFC2 reduced the number of intracellular M. tuberculosis in macrophages in a dose-dependent manner. Taken together, our results indicate DFC2 to be promising new candidate agents for the treatment of tuberculosis.
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Collections - College of Natural Sciences > Department of Biology > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Microbiology > 1. Journal Articles
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