Relationship between 25-Hydroxyvitamin D Levels and Liver Fibrosis as Assessed by Transient Elastography in Patients with Chronic Liver Disease
- Authors
- Ko, Bong Jin; Kim, Young Seok; Kim, Sang Gyune; Park, Jung Hwan; Lee, Sae Hwan; Jeong, Soung Won; Jang, Jae Young; Kim, Hong Soo; Kim, Boo Sung; Kim, Sun Mi; Kim, Young Don; Cheon, Gab Jin; Lee, Bo Ra
- Issue Date
- Sep-2016
- Publisher
- 거트앤리버 발행위원회
- Keywords
- 25-Hydroxyvitamin D deficiency; Transient elastography; Liver stiffness
- Citation
- Gut and Liver, v.10, no.5, pp 818 - 825
- Pages
- 8
- Journal Title
- Gut and Liver
- Volume
- 10
- Number
- 5
- Start Page
- 818
- End Page
- 825
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/8818
- DOI
- 10.5009/gnl15331
- ISSN
- 1976-2283
2005-1212
- Abstract
- Background/Aims: Deficiencies of 25-hydroxyvitamin D (25(OH)D) are prevalent in patients with chronic liver disease (CLD). Liver fibrosis is the main determinant of CLD prognosis. The present study was performed to evaluate the correlation between 25(OH)D levels and liver fibrosis as assessed by transient elastography (TE) in patients with compensated CLD. Methods: Serum 25(OH)D levels and liver stiffness were determined in a total of 207 patients who were subjected to the following exclusion criteria: patients with decompensated CLD; patients who had malignancies; patients who were taking medications; and patients who were pregnant. Results: The most common etiology was chronic hepatitis B (53.1%). Advanced liver fibrosis (defined by TE [>= 9.5 kPa]) was present in 75 patients (36.2%). There was a significant correlation between 25(OH)D deficiency and liver stiffness. Based on the multivariate analysis, the following factors were independently associated with advanced liver fibrosis: 25(OH)D deficiency (odds ratio [OR], 3.46; p=0.004), diabetes mellitus (OR, 3.04; p=0.041), and fibrosis-4 index (OR, 2.01; p<0.001). Conclusions: Patients with compensated CLD exhibit a close correlation between vitamin D. level and liver stiffness as assessed by TE. Vitamin D deficiency was independently associated with advanced liver fibrosis.
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
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