Ten-day empirical sequential or concomitant therapy is more effective than triple therapy for Helicobacter pylori eradication: A multicenter, prospective study
- Authors
- Chung, Jun-Won; Han, Jae Pil; Kim, Kyoung Oh; Kim, Su Young; Hong, Su Jin; Kim, Tae Ho; Kim, Chang Whan; Kim, Joon Sung; Kim, Byung-Wook; Bang, Byoung Wook; Kim, Hyung Gil; Yun, Sung-Cheol
- Issue Date
- Aug-2016
- Publisher
- W. B. Saunders Co., Ltd.
- Keywords
- Antibiotic resistance; Clarithromycin; Helicobacter pylori; Metronidazole
- Citation
- Digestive and Liver Disease, v.48, no.8, pp 888 - 892
- Pages
- 5
- Journal Title
- Digestive and Liver Disease
- Volume
- 48
- Number
- 8
- Start Page
- 888
- End Page
- 892
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/8902
- DOI
- 10.1016/j.dld.2016.05.005
- ISSN
- 1590-8658
1878-3562
- Abstract
- Background: The resistance of Helicobacter pylori to antibiotics has increased the need for new empirical, first-line treatments. However, the efficacy of sequential therapy (ST) and concomitant therapy (CT) compared with triple therapy (TT) has not been adequately evaluated. Aim: In this study, we evaluated the efficacy of these empirical three regimens. Methods: The 517 patients enrolled in the study were prospectively randomized to receive 10 days of TT (n = 171), ST (n = 170), and CT (n = 176) at 5 university-affiliated hospitals from May 2013 to March 2015. The post-treatment H. pylori status was determined using the C-13-urea breath test. Results: The baseline characteristics were similar among the three groups. The intention-to-treat eradication rates were 62.6%, 70.6%, and 77.8% in the TT, ST, and CT groups, respectively (p<0.01). The corresponding per-protocol eradication rates were 82.8%, 89.5%, and 94.4%, respectively (p<0.01). There were no significant differences in the compliance, side effects, and follow-up loss rates. Conclusion: A higher eradication rate was achieved with empirical 10-day ST, and CT than with the TT regimen, with similar rates of compliance and treatment side effects. (C) 2016 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
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