Family History and Risk of Recurrent Stroke
- Authors
- Chung, Jong-Won; Kim, Beom Joon; Han, Moon-Ku; Kang, Kyusik; Park, Jong-Moo; Park, Sang-Soon; Park, Tai Hwan; Cho, Yong-Jin; Hong, Keun-Sik; Lee, Kyung Bok; Kim, Jae Guk; Ko, Youngchai; Lee, SooJoo; Nah, Hyun-Wook; Kim, Dae-Hyun; Cha, Jae-Kwan; Oh, Mi-Sun; Yu, Kyung-Ho; Lee, Byung-Chul; Jang, Myung Suk; Lee, Ji Sung; Lee, Juneyoung; Bae, Hee-Joon
- Issue Date
- Aug-2016
- Publisher
- Lippincott Williams & Wilkins Ltd.
- Keywords
- ischemia; prognosis; proportional hazard models; risk assessment; stroke
- Citation
- Stroke, v.47, no.8, pp 1990 - 1996
- Pages
- 7
- Journal Title
- Stroke
- Volume
- 47
- Number
- 8
- Start Page
- 1990
- End Page
- 1996
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/8910
- DOI
- 10.1161/STROKEAHA.116.013148
- ISSN
- 0039-2499
1524-4628
- Abstract
- Background and Purpose-The association between family history of stroke and stroke recurrence remains unclear. Methods-Using a web-based multicenter stroke registry database, information on history of stroke in first-degree relatives was collected prospectively for acute ischemic stroke patients who were hospitalized within 7 days of onset. The collected information was categorized as follows: type of the affected relative(s) with stroke (paternal, maternal, sibling, or 2 or more) and age of the relative's stroke onset (<50, 50-59, 60-69, and >= 70 years). Stroke recurrence was captured prospectively using a predetermined protocol. Subgroup analyses were performed according to the patient's age at the index stroke. Results-Among 7642 patients, 937 (12.3%) had a history of stroke in their first-degree relatives and 475 (6.2%: 201 within and 274 after 3 weeks from index stroke) experienced stroke recurrence (median follow-up, 365 days). In multivariable Cox proportional hazard models, overall family history was not associated with stroke recurrence (hazard ratio, 1.08; 95% confidence interval, 0.81-1.43). However, the details of their family histories, including relative's age at stroke onset (<50 years: hazard ratio, 2.14; 95% confidence interval, 1.004-4.54) and stroke history in a sibling (hazard ratio, 1.67; 95% confidence interval, 1.09-2.58), were independently associated with stroke recurrence after adjusting for potential confounders. The associations appeared to be stronger in young adults with stroke (age, <55 years) than in older stroke patients. Conclusions-This study suggests that elevated risks of recurrent stroke are associated with having relatives with early-onset stroke and siblings with stroke histories, implying that additional precautions may be needed in such populations.
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Collections - College of Medicine > Department of Neurology > 1. Journal Articles
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