Expression of Aquaporin-6 in Rat Retinal Ganglion Cells
- Authors
- Jang, Sun Young; Lee, Eung Suk; Ohn, Young-Hoon; Park, Tae Kwann
- Issue Date
- Aug-2016
- Publisher
- Kluwer Academic/Plenum Publishers
- Keywords
- Aquaporin-6; Rat; Retina; Ganglion cells; Muller cells
- Citation
- Cellular and Molecular Neurobiology, v.36, no.6, pp 965 - 970
- Pages
- 6
- Journal Title
- Cellular and Molecular Neurobiology
- Volume
- 36
- Number
- 6
- Start Page
- 965
- End Page
- 970
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/8930
- DOI
- 10.1007/s10571-015-0283-6
- ISSN
- 0272-4340
1573-6830
- Abstract
- Several aquaporins (AQPs) have been identified to be present in the eyes, and it has been suggested that they are involved in the movement of water and small solutes. AQP6, which has low water permeability and transports mainly anions, was recently discovered in the eyes. In the present study, we investigate the localization of AQP6 in the rat retina and show that AQP6 is selectively localized to the ganglion cell layer and the outer plexiform layer. Along with the gradual decrease in retinal ganglion cells after a crushing injury of optic nerve, immunofluorescence signals of AQP6 gradually decreased. Confocal microscope images confirmed AQP6 expression in retinal ganglion cells and Muller cells in vitro. Therefore, AQP6 might participate in water and anion transport in these cells.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Ophthalmology > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/8930)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.