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Enantioselective addition of diphenyl phosphonate to ketimines derived from isatins catalyzed by binaphthyl-modified organocatalysts

Authors
Jang, Hee SeungKim, YubinKim, Dae Young
Issue Date
20-Jul-2016
Publisher
Beilstein-Institut
Keywords
3-amino-3-phosphonyl-substituted oxindole; alpha-aminophosphonates; bifunctional organocatalyst; ketimines; organocatalysis; squaramide
Citation
Beilstein Journal of Organic Chemistry, v.12, pp 1551 - 1556
Pages
6
Journal Title
Beilstein Journal of Organic Chemistry
Volume
12
Start Page
1551
End Page
1556
URI
https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/8934
DOI
10.3762/bjoc.12.149
ISSN
1860-5397
Abstract
Chiral binaphthyl-modified squaramide-catalyzed enantioselective addition of diphenyl phosphonate to ketimines derived from isatins has been achieved. This method affords practical and efficient access to chiral 3-amino-3-phosphonyl-substituted oxindole derivatives in high yields with excellent enantioselectivities (up to 99% ee).
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